Drug General Information
Drug ID	D06GNE
Former ID	DIB019770
Drug Name	IC86621
Synonyms	IC86621
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[541240]
Structure		Download 2D MOL
Formula	C12H15NO3
InChI	InChI=1S/C12H15NO3/c1-9(14)11-3-2-10(8-12(11)15)13-4-6-16-7-5-13/h2-3,8,15H,4-7H2,1H3
InChIKey	YHKSBKQXCWHTQL-UHFFFAOYSA-N
PubChem Compound ID	9859309
PubChem Substance ID	14822702, 24152678, 24895962, 26758567, 29217565, 45281604, 53800803, 57373578, 76935239, 85845066, 99302650, 121379634, 137013883, 139537292, 162248649, 162527473, 163315731, 163347060, 163688272, 164213621, 175607399, 178102583, 179042908, 184818063, 188942255, 204375287, 208265013, 208265533, 212559559, 226902925, 249127951, 252483881
Target and Pathway
Target(s)	DNA-dependent protein kinase catalytic subunit	Target Info	Inhibitor	[531979]
KEGG Pathway	Non-homologous end-joining
	Cell cycle
NetPath Pathway	IL1 Signaling Pathway
Pathway Interaction Database	DNA-PK pathway in nonhomologous end joining
	Coregulation of Androgen receptor activity
	Class I PI3K signaling events mediated by Akt
	BARD1 signaling events
Reactome	Nonhomologous End-Joining (NHEJ)
WikiPathways	DNA Damage Response
	Non-homologous end joining
	FAS pathway and Stress induction of HSP regulation
	Cytosolic sensors of pathogen-associated DNA
	Retinoblastoma (RB) in Cancer
	Prostate Cancer
	Double-Strand Break Repair
	Cell Cycle
	miRNA Regulation of DNA Damage Response
References
Ref 541240	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5960).
Ref 531979	Modulation of DNA repair by pharmacological inhibitors of the PIKK protein kinase family. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5352-9.

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