TTD | Drug: D06III

Drug General Information
Drug ID	D06III
Former ID	DIB020511
Drug Name	NE10790
Synonyms	NE 10790
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[540149]
Structure		Download 2D MOL
Formula	C8H10NO6P
InChI	InChI=1S/C8H10NO6P/c10-7(11)8(12,16(13,14)15)4-6-2-1-3-9-5-6/h1-3,5,12H,4H2,(H,10,11)(H2,13,14,15)
InChIKey	FJVYPXVLXQXDHM-UHFFFAOYSA-N
PubChem Compound ID	10014835
PubChem Substance ID	14995440, 22445760, 44106930, 78308976, 103542335, 104096938, 127857817, 134222679, 135650697, 141935542, 230777613
Target and Pathway
Target(s)	Farnesyl pyrophosphatesynthetase	Target Info	Inhibitor	[529362]
KEGG Pathway	Terpenoid backbone biosynthesis
	Metabolic pathways
	Biosynthesis of antibiotics
	Influenza A
	HTLV-I infection
PathWhiz Pathway	Steroid Biosynthesis
Reactome	Cholesterol biosynthesis
Reactome	Activation of gene expression by SREBF (SREBP)
WikiPathways	Activation of Gene Expression by SREBP (SREBF)
	SREBP signalling
	Cholesterol Biosynthesis
References
Ref 540149	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3165).
Ref 529362	J Med Chem. 2008 Apr 10;51(7):2187-95. Epub 2008 Mar 8.Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase.

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Drug Information