Drug Information

Drug General Information
Drug ID
D06IRE
Former ID
DIB021085
Drug Name
trichloroethanol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539444]
Structure
Download
2D MOL
Formula
C2H3Cl3O
InChI
InChI=1S/C2H3Cl3O/c3-2(4,5)1-6/h6H,1H2
InChIKey
KPWDGTGXUYRARH-UHFFFAOYSA-N
PubChem Compound ID
8259
PubChem Substance ID
9693, 111467, 588139, 3134731, 7544284, 8144399, 8155783, 10504520, 12157173, 14709318, 15170878, 24900284, 29226971, 30952970, 33677449, 46394402, 48415142, 49968122, 57324883, 57389600, 74778195, 85090041, 87226434, 87576514, 88822997, 93617816, 103341628, 104317345, 113635236, 117618557, 125362849, 126546633, 126687820, 127280530, 127280531, 127280532, 127838658, 128131370, 128417629, 134974720, 135651278, 137004033, 142343713, 144087425, 162075472, 162124593, 162303546, 162757963, 163411210, 163849184
Target and Pathway
Target(s) 5-HT3AB Target Info Modulator (allosteric modulator) [527834]
5-hydroxytryptamine receptor 3A Target Info Modulator (allosteric modulator) [529227]
KEGG Pathway Serotonergic synapse
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway 5HT3 type receptor mediated signaling pathway
Reactome Ligand-gated ion channel transport
WikiPathways SIDS Susceptibility Pathways
Iron uptake and transport
References
Ref 539444(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2293).
Ref 527834Co-expression of the 5-HT(3B) subunit with the 5-HT(3A) receptor reduces alcohol sensitivity. Brain Res Mol Brain Res. 2005 Dec 14;142(2):146-50. Epub 2005 Oct 28.
Ref 529227Arginine 246 of the pretransmembrane domain 1 region alters 2,2,2-trichloroethanol action in the 5-hydroxytryptamine3A receptor. J Pharmacol Exp Ther. 2008 Mar;324(3):1011-8. Epub 2007 Dec 19.

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