Drug General Information
Drug ID	D06KHR
Former ID	DIB019709
Drug Name	decavanadate
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[539586]
Structure		Download 2D MOL
Formula	O28V10-6
InChI	InChI=1S/28O.10V/q;;;;;;;;;;;;;;;;;;;;;;6*-1;;;;;;;;;;
InChIKey	OSBWBKHFRWKREF-UHFFFAOYSA-N
PubChem Compound ID	5311062
PubChem Substance ID	7979032, 51213846, 135652750
Target and Pathway
Target(s)	P2X purinoceptor 7	Target Info	Antagonist	[528045]
	TRPM4	Target Info	Activator	[527184]
	IP3R3	Target Info	Antagonist	[543957]
	IP3R2	Target Info	Antagonist	[543956]
	IP3R1	Target Info	Antagonist	[543955]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
Reactome	The NLRP3 inflammasome
WikiPathways	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
References
Ref 539586	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2459).
Ref 527184	Decavanadate modulates gating of TRPM4 cation channels. J Physiol. 2004 Nov 1;560(Pt 3):753-65. Epub 2004 Aug 26.
Ref 528045	Decavanadate, a P2X receptor antagonist, and its use to study ligand interactions with P2X7 receptors. Eur J Pharmacol. 2006 Mar 18;534(1-3):19-29. Epub 2006 Feb 17.
Ref 543955	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 743).
Ref 543956	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 744).
Ref 543957	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 745).

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