Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D06KTY
|
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| Former ID |
DNC000890
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| Drug Name |
Loxiglumide
|
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| Drug Type |
Small molecular drug
|
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| Structure |
|
Download2D MOL |
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| Formula |
C21H30Cl2N2O5
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| InChI |
InChI=1S/C21H30Cl2N2O5/c1-3-4-5-11-25(12-6-13-30-2)21(29)18(9-10-19(26)27)24-20(28)15-7-8-16(22)17(23)14-15/h7-8,14,18H,3-6,9-13H2,1-2H3,(H,24,28)(H,26,27)
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| InChIKey |
QNQZBKQEIFTHFZ-UHFFFAOYSA-N
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| CAS Number |
CAS 107097-80-3
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
7848176, 8186711, 12014112, 14858173, 43117613, 50002824, 50595051, 57313995, 85209678, 103483749, 104069481, 104320084, 117462170, 125823047, 126666685, 129049181, 134339776, 134340190, 135016969, 135650534, 137246280, 137267638, 152343551, 162011536, 170465971, 174526056, 175612456, 179149551, 184546007, 223654106, 226715875, 242060146, 249582653, 252351363
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| Target and Pathway | |||||
| Target(s) | CCK receptor | Target Info | Antagonist | [538000] | |
| Cholecystokinin receptor type A | Target Info | Antagonist | [535619] | ||
| References | |||||
| Ref 530560 | Effects of CCK receptor blockade on intestinal motor activity in conscious dogs. Am J Physiol. 1991 Feb;260(2 Pt 1):G315-24. | ||||
| Ref 543284 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 892). | ||||
| Ref 535619 | Role of CCK(A) receptors in postprandial lower esophageal sphincter function in morbidly obese subjects. Dig Dis Sci. 2002 Nov;47(11):2531-7. | ||||
| Ref 538000 | Cholecystokinin receptor antagonist, loxiglumide, inhibits invasiveness of human pancreatic cancer cell lines. FEBS Lett. 1996 Apr 1;383(3):241-4. | ||||
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