Drug General Information
Drug ID	D06LFV
Former ID	DCL000179
Drug Name	NM-702
Drug Type	Small molecular drug
Indication	Angina pectoris [ICD9: 413; ICD10:I20]		Phase 3	[544180]
Company	Nissan Chemical America
Structure		Download 2D MOL 3D MOL
Formula	C19H19BrCl2N4O2
Canonical SMILES	C1=CC(=CN=C1)CNC2=C(C(=O)NN=C2OCCCC3=CC=C(C=C3)Cl)Br.Cl
InChIKey	QWGUGDYWUADMGB-UHFFFAOYSA-N
CAS Number	CAS 878796-94-2
PubChem Compound ID	9848253
PubChem Substance ID	14810325, 24144883, 44946319, 79967329, 125259484, 135262323, 227920291
Target and Pathway
Target(s)	Phosphodiesterase	Target Info	Inhibitor	[536325]
	Thromboxane-A synthase	Target Info	Inhibitor	[536325]
BioCyc Pathway	C20 prostanoid biosynthesis
KEGG Pathway	Arachidonic acid metabolism
	Metabolic pathways
	Platelet activation
PathWhiz Pathway	Arachidonic Acid Metabolism
WikiPathways	Prostaglandin Synthesis and Regulation
	Arachidonic acid metabolism
	Phase 1 - Functionalization of compounds
	Eicosanoid Synthesis
References
Ref 544180	Application of adaptive design and decision making to a phase II trial of a phosphodiesterase inhibitor for the treatment of intermittent claudication. Trials. 2011; 12: 134.
Ref 536325	The novel phosphodiesterase inhibitor NM-702 improves claudication-limited exercise performance in patients with peripheral arterial disease. J Am Coll Cardiol. 2006 Dec 19;48(12):2539-45. Epub 2006Nov 28.

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