Drug Information

Drug General Information
Drug ID
D06NUL
Former ID
DNC003755
Drug Name
RWJ-68354
Drug Type
Small molecular drug
Indication Discovery agent Investigative [526530]
Structure
Download
2D MOL

3D MOL
Formula
C19H15FN4O
Canonical SMILES
COC1=CC(=NC2=C1C(=C(N2)C3=CC=C(C=C3)F)C4=CC=NC=C4)N
InChI
1S/C19H15FN4O/c1-25-14-10-15(21)23-19-17(14)16(11-6-8-22-9-7-11)18(24-19)12-2-4-13(20)5-3-12/h2-10H,1H3,(H3,21,23,24)
InChIKey
ADQZGIYHFQQPRB-UHFFFAOYSA-N
PubChem Compound ID
9819053
Target and Pathway
Target(s) Mitogen-activated protein kinase 11 Target Info Inhibitor [526530]
Mitogen-activated protein kinase 14 Target Info Inhibitor [526530]
MAP kinase p38 Target Info Inhibitor [526530]
KEGG Pathway MAPK signaling pathway
Rap1 signaling pathway
FoxO signaling pathway
Sphingolipid signaling pathway
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Signaling pathways regulating pluripotency of stem cells
Platelet activation
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
RIG-I-like receptor signaling pathway
T cell receptor signaling pathway
Fc epsilon RI signaling pathway
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Retrograde endocannabinoid signaling
Dopaminergic synapse
Inflammatory mediator regulation of TRP channels
GnRH signaling pathway
Progesterone-mediated oocyte maturation
Prolactin signaling pathway
Amyotrophic lateral sclerosis (ALS)
Epithelial cell signaling in Helicobacter pylori infection
Shigellosis
Salmonella infection
Pertussis
Leishmaniasis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Tuberculosis
Hepatitis C
Influenza A
Epstein-Barr virus infection
Proteoglycans in cancerhsa04010:MAPK signaling pathway
Oocyte meiosis
Proteoglycans in cancer
NetPath Pathway IL5 Signaling Pathway
FSH Signaling Pathway
TCR Signaling PathwayNetPath_11:TCR Signaling Pathway
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
B cell activation
EGF receptor signaling pathway
FGF signaling pathway
Interferon-gamma signaling pathway
Oxidative stress response
TGF-beta signaling pathway
Ras Pathway
p53 pathway feedback loops 2
p38 MAPK pathwayP00003:Alzheimer disease-amyloid secretase pathway
Angiogenesis
Parkinson disease
Toll receptor signaling pathway
VEGF signaling pathway
p38 MAPK pathway
CCKR signaling map STP00003:Alzheimer disease-amyloid secretase pathway
Pathway Interaction Database p73 transcription factor network
p38 MAPK signaling pathway
Plasma membrane estrogen receptor signaling
CD40/CD40L signaling
Regulation of p38-alpha and p38-beta
FAS (CD95) signaling pathway
Thromboxane A2 receptor signaling
Glucocorticoid receptor regulatory network
IL2-mediated signaling events
Rapid glucocorticoid signaling
ATF-2 transcription factor network
IL6-mediated signaling events
p38 signaling mediated by MAPKAP kinases
CXCR3-mediated signaling events
Signaling mediated by p38-alpha and p38-beta
Signaling events mediated by VEGFR1 and VEGFR2
VEGFR3 signaling in lymphatic endothelium
Regulation of retinoblastoma proteinendothelinpathway:Endothelins
BCR signaling pathway
Atypical NF-kappaB pathway
IL4-mediated signaling events
IL12-mediated signaling events
CDC42 signaling events
Angiopoietin receptor Tie2-mediated signaling
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Regulation of Androgen receptor activity
Retinoic acid receptors-mediated signaling
EPO signaling pathway
p53 pathway
S1P2 pathway
Trk receptor signaling mediated by the MAPK pathway
FGF signaling pathway
RAC1 signaling pathway
Regulation of retinoblastoma proteinrhoa_pathway:RhoA signaling pathway
Signaling mediated by p38-gamma and p38-delta
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Intracellular Signalling Through Adenosine Receptor A2b and AdenosinePW000453:Fc Epsilon Receptor I Signaling in Mast Cells
Reactome NOD1/2 Signaling Pathway
p38MAPK events
ERK/MAPK targets
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Oxidative Stress Induced Senescence
CDO in myogenesis
DSCAM interactions
VEGFA-VEGFR2 Pathway
activated TAK1 mediates p38 MAPK activation
Activation of the AP-1 family of transcription factors
KSRP (KHSRP) binds and destabilizes mRNAR-HSA-168638:NOD1/2 Signaling Pathway
ADP signalling through P2Y purinoceptor 1
Platelet sensitization by LDL
WikiPathways Toll-like receptor signaling pathway
Insulin Signaling
IL-4 Signaling Pathway
MAP kinase activation in TLR cascade
Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
Nanoparticle-mediated activation of receptor signaling
Structural Pathway of Interleukin 1 (IL-1)
Parkinsons Disease Pathway
NGF signalling via TRKA from the plasma membrane
Myogenesis
DSCAM interactions
Physiological and Pathological Hypertrophy of the Heart
Regulation of toll-like receptor signaling pathwayWP75:Toll-like receptor signaling pathway
Monoamine Transport
Serotonin HTR1 Group and FOS Pathway
TCR Signaling Pathway
Senescence and Autophagy in Cancer
Interferon type I signaling pathways
EGF/EGFR Signaling Pathway
MAPK Cascade
Oxidative Stress
p38 MAPK Signaling Pathway
MAPK Signaling Pathway
TGF beta Signaling Pathway
Kit receptor signaling pathway
Cardiac Hypertrophic Response
JAK/STAT
Amyotrophic lateral sclerosis (ALS)
Alpha 6 Beta 4 signaling pathway
Cardiac Progenitor Differentiation
BDNF signaling pathway
Integrated Pancreatic Cancer Pathway
Oncostatin M Signaling Pathway
Corticotropin-releasing hormone
AGE/RAGE pathway
B Cell Receptor Signaling Pathway
Prostate Cancer
TSLP Signaling Pathway
TWEAK Signaling Pathway
FSH signaling pathway
Leptin signaling pathway
RANKL/RANK Signaling Pathway
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in leukocytes - TarBase
miR-targeted genes in epithelium - TarBase
IL-1 signaling pathway
Signal amplification
Platelet homeostasis
MicroRNAs in cardiomyocyte hypertrophy
Angiogenesis
Signal Transduction of S1P Receptor
Integrin-mediated Cell Adhesion
Regulation of toll-like receptor signaling pathway
References
Ref 526530Bioorg Med Chem Lett. 2003 Feb 10;13(3):347-50.Imidazopyrimidines, potent inhibitors of p38 MAP kinase.
Ref 526530Bioorg Med Chem Lett. 2003 Feb 10;13(3):347-50.Imidazopyrimidines, potent inhibitors of p38 MAP kinase.

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