Drug Information

Drug General Information
Drug ID
D06OAH
Former ID
DNC007554
Drug Name
6-bromoindirubin-3-oxime
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541250]
Structure
Download
2D MOL

3D MOL
Formula
C16H10BrN3O2
InChI
InChI=1S/C16H10BrN3O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)15-14(20-22)10-3-1-2-4-11(10)18-15/h1-7,20,22H,(H,19,21)/b15-13-
InChIKey
WNWSUJQVZJJGLF-SQFISAMPSA-N
PubChem Compound ID
5287844
PubChem Substance ID
833555, 7886348, 14747233, 15002478, 24724412, 26753605, 26753606, 26758803, 26758805, 29215160, 39320384, 46393346, 46507596, 48244433, 48431446, 56339573, 57359194, 57550078, 76874466, 85752750, 85756489, 90341740, 91148008, 99302717, 103029097, 103566428, 104074524, 104092357, 113870608, 121361652, 121560411, 123103467, 123220362, 124659179, 134344759, 135698600, 141713899, 141713900, 141713902, 141713903, 141713904, 160966566, 163338681, 163564727, 163688038, 163688040, 172089031, 172916913, 174520444, 175607663
Target and Pathway
Target(s) mRNA of Aurora B Target Info Inhibitor [528968]
Aurora kinase A Target Info Inhibitor [528968]
Aurora protein kinase Target Info Inhibitor [528968]
KEGG Pathway Oocyte meiosishsa04114:Oocyte meiosis
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Aurora C signaling
FOXM1 transcription factor network
Aurora A signalingaurora_b_pathway:Aurora B signaling
Integrin-linked kinase signaling
PLK1 signaling events
Aurora A signaling
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic PrometaphaseR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M TransitionR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
WikiPathways Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Regulation of Microtubule Cytoskeleton
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
APC/C-mediated degradation of cell cycle proteinsWP437:EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteins
References
Ref 541250(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5974).
Ref 528968J Med Chem. 2007 Aug 23;50(17):4027-37. Epub 2007 Aug 1.An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins.

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