Drug Information

Drug General Information
Drug ID
D06PAZ
Former ID
DAP000519
Drug Name
Encainide
Synonyms
Encainida; Encainidum; Enkaid; Encainida [Spanish]; Encainide [French]; Encainidum [Latin]; No stereochem; MJ 9067; Encainide (INN); Encainide [INN:BAN]; MJ-9067; MJ-9067-1; Encainide Hydrochloride, (+-)-Isomer; (+-)-2'-[2-(1-methyl-2-piperidyl)ethyl]-p-anisanilide; (+-)-4-Methoxy-N-(2-(2-(1-methyl-2-piperidinyl)ethyl)phenyl)benzamide; (+/-)-4-Methoxy-N-[2-[2-(1-methyl-2-piperidinyl)ethyl]phenyl]benzamide; 4-methoxy-2'-[2-(1-methyl-2-piperidyl)ethyl]benzanilide; 4-methoxy-N-[2-[2-(1-methylpiperidin-2-yl)ethyl]phenyl]benzamide; 4-methoxy-N-{2-[2-(1-methylpiperidin-2-yl)ethyl]phenyl}benzamide
Drug Type
Small molecular drug
Indication Heart arrhythmia [ICD10:I47-I49] Withdrawn from market [537733], [551871]
Therapeutic Class
Antiarrhythmic Agents
Structure
Download
2D MOL

3D MOL
Formula
C22H28N2O2
Canonical SMILES
CN1CCCCC1CCC2=CC=CC=C2NC(=O)C3=CC=C(C=C3)OC
InChI
1S/C22H28N2O2/c1-24-16-6-5-8-19(24)13-10-17-7-3-4-9-21(17)23-22(25)18-11-14-20(26-2)15-12-18/h3-4,7,9,11-12,14-15,19H,5-6,8,10,13,16H2,1-2H3,(H,23,25)
InChIKey
PJWPNDMDCLXCOM-UHFFFAOYSA-N
CAS Number
CAS 66778-36-7
PubChem Compound ID
48041
PubChem Substance ID
9192, 6165533, 7979158, 8180518, 12012630, 15373859, 34712961, 46504470, 48415942, 49877070, 50064743, 57313176, 80562377, 96024590, 99313642, 104354474, 117563414, 124896651, 125749069, 126666719, 128926702, 134223157, 134337811, 135007178, 135049140, 137231478, 142970991, 162518740, 163693531, 163852995, 172892145, 179225703, 184536609, 184547004, 194147897, 196396473, 203084558, 223669045, 224787244, 225384108, 226471947, 241066723, 249965307, 252345471
SuperDrug ATC ID
C01BC08
SuperDrug CAS ID
cas=066778367
Target and Pathway
Target(s) Sodium channel protein type 5 subunit alpha Target Info Blocker [537980]
KEGG Pathway Adrenergic signaling in cardiomyocytes
PathWhiz Pathway Muscle/Heart Contraction
Reactome Interaction between L1 and Ankyrins
WikiPathways SIDS Susceptibility Pathways
Cardiac Progenitor Differentiation
References
Ref 537733New antiarrhythmic drugs: tocainide, mexiletine, flecainide, encainide, and amiodarone. Mayo Clin Proc. 1987 Nov;62(11):1033-50.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 537980From first class to third class: recent upheaval in antiarrhythmic therapy--lessons from clinical trials. Am J Cardiol. 1996 Aug 29;78(4A):28-33.

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