Drug Information

Drug General Information
Drug ID
D06PXY
Former ID
DIB018815
Drug Name
alpha-ergocryptine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539770]
Structure
Download
2D MOL
Formula
C32H41N5O5
InChI
InChI=1S/C32H41N5O5/c1-17(2)12-25-29(39)36-11-7-10-26(36)32(41)37(25)30(40)31(42-32,18(3)4)34-28(38)20-13-22-21-8-6-9-23-27(21)19(15-33-23)14-24(22)35(5)16-20/h6,8-9,13,15,17-18,20,24-26,33,41H,7,10-12,14,16H2,1-5H3,(H,34,38)/t20-,24-,25+,26+,31-,32+/m1/s1
InChIKey
YDOTUXAWKBPQJW-NSLWYYNWSA-N
PubChem Compound ID
134551
PubChem Substance ID
9748, 10321972, 10645176, 11466755, 11467875, 11486329, 15232779, 24894618, 29312230, 47350623, 47647744, 47721858, 48020241, 48244658, 48395147, 48484180, 49698625, 56463649, 57344920, 78965346, 85788371, 92125620, 99319091, 103914441, 104382386, 121363291, 122859598, 124559164, 124800038, 129780413, 135652665, 135727635, 137041941, 139699234, 141839363, 160698676, 160870076, 162221606, 179214378, 198986633, 224852914, 226458154, 241178188, 241201541, 250134878, 252345021, 252448634
Target and Pathway
Target(s) 5-hydroxytryptamine 6 receptor Target Info Antagonist [534734]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 539770(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 271).
Ref 534734Identification of residues in transmembrane regions III and VI that contribute to the ligand binding site of the serotonin 5-HT6 receptor. J Neurochem. 1998 Nov;71(5):2169-77.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.