Drug Information

Drug General Information
Drug ID
D06PZN
Former ID
DNC000959
Drug Name
Mosapride
Drug Type
Small molecular drug
Indication Discovery agent Phase 4 [524637], [539549]
Structure
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2D MOL

3D MOL
Formula
C21H25ClFN3O3
InChI
InChI=1S/C21H25ClFN3O3/c1-2-28-20-10-19(24)18(22)9-17(20)21(27)25-11-16-13-26(7-8-29-16)12-14-3-5-15(23)6-4-14/h3-6,9-10,16H,2,7-8,11-13,24H2,1H3,(H,25,27)
InChIKey
YPELFRMCRYSPKZ-UHFFFAOYSA-N
CAS Number
CAS 112885-41-3
PubChem Compound ID
119584
PubChem Substance ID
10238548, 14856046, 29216210, 29300427, 47434920, 48254040, 49875381, 50110109, 53346072, 57339567, 85209635, 90452581, 92720568, 93374710, 93626124, 96024924, 103250420, 103923914, 104408671, 117843401, 125324809, 125338080, 126607121, 126619873, 126648433, 126666115, 129828067, 131294814, 131294815, 131813325, 134340239, 135134188, 135650625, 135683234, 136373748, 137249282, 137541651, 143504192, 144108846, 160809785, 162035093, 162181032, 163088239, 164035874, 164175206, 164814860, 166236538, 172090760, 172842270, 174006284
Target and Pathway
Target(s) 5-hydroxytryptamine 4 receptor Target Info Agonist [536689]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT4 type receptor mediated signaling pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 4 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 524637ClinicalTrials.gov (NCT02056405) Effect of Mosapride on Postoperative Ileus in Patients Undergoing Colorectal Surgery. U.S. National Institutes of Health.
Ref 539549(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 242).
Ref 536689The in vitro pharmacological profile of TD-5108, a selective 5-HT(4) receptor agonist with high intrinsic activity. Naunyn Schmiedebergs Arch Pharmacol. 2008 Jul;378(1):125-37. Epub 2008 Apr 16.

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