Drug Information

Drug General Information
Drug ID
D06RCB
Former ID
DAP000914
Drug Name
Diethylcarbamazine
Synonyms
Bitirazine; Camin; Caracide; Carbamazine; Carbilazine; Caricide; Cypip; Decacide; Diaethylcarbamazinum; Diethylcarbamazinum; Dietilcarbamazina; Ethodryl; Luxuran; Notezine; Spatonin; Diethyl carbamazine; Ditrazine Base; Banocide (TN); Camin (TN); Carbilazine (TN); Caricide (TN); Cypip (TN); Diethylcarbamazine (INN); Diethylcarbamazine [INN:BAN]; Diethylcarbamazinum [INN-Latin]; Dietilcarbamazina [INN-Spanish]; Ethodryl (TN); FR-1031; Filaribits (TN); Forte (TN); Hetrazan (TN); Spatonin (TN); N,N-Diethyl-4-methyl-1-piperazinecarboxamide; N,N-diethyl-4-methylpiperazine-1-carboxamide; 1-Diethylcarbamyl-4-methylpiperazine; 84L
Drug Type
Small molecular drug
Indication Lymphatic filariasis [ICD9: 125; ICD10:B74] Approved [536135], [551871]
Therapeutic Class
Anthelmintics
Company
Lederle Laboratories Div American Cyanamid Co
Structure
Download
2D MOL

3D MOL
Formula
C10H21N3O
Canonical SMILES
CCN(CC)C(=O)N1CCN(CC1)C
InChI
1S/C10H21N3O/c1-4-12(5-2)10(14)13-8-6-11(3)7-9-13/h4-9H2,1-3H3
InChIKey
RCKMWOKWVGPNJF-UHFFFAOYSA-N
CAS Number
CAS 90-89-1
PubChem Compound ID
3052
PubChem Substance ID
10169, 603056, 5635251, 7979075, 8151942, 10537738, 11335723, 11360962, 11363832, 11366394, 11368956, 11371499, 11374220, 11377118, 11461934, 11466312, 11467432, 11484939, 11486143, 11488838, 11490206, 11492326, 11494752, 15414101, 29199083, 29222198, 46506830, 47216750, 47216751, 47216752, 47440221, 47515292, 47810725, 47885379, 48415888, 49698856, 50011676, 50123452, 50123453, 50263820, 57321580, 85788399, 96024522, 103191069, 103905855, 104302387, 107815220, 118238838, 124596531, 125623992
SuperDrug ATC ID
P02CB02
SuperDrug CAS ID
cas=000090891
Target and Pathway
Target(s) Arachidonate 5-lipoxygenase Target Info Inhibitor [534910]
BioCyc Pathway Aspirin-triggered lipoxin biosynthesis
Resolvin D biosynthesis
Leukotriene biosynthesis
Lipoxin biosynthesis
Aspirin triggered resolvin D biosynthesis
Aspirin triggered resolvin E biosynthesis
KEGG Pathway Arachidonic acid metabolism
Metabolic pathways
Serotonergic synapse
Ovarian steroidogenesis
Toxoplasmosis
NetPath Pathway IL4 Signaling Pathway
PathWhiz Pathway Arachidonic Acid Metabolism
WikiPathways Vitamin D Receptor Pathway
Arachidonic acid metabolism
Eicosanoid Synthesis
Selenium Micronutrient Network
References
Ref 536135Opportunities and challenges in antiparasitic drug discovery. Nat Rev Drug Discov. 2005 Sep;4(9):727-40.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 534910Inhibition of leukotriene formation by diethylcarbamazine modifies the acid-base balance in the rabbits with blast injuries of the lungs. Vojnosanit Pregl. 1999 May-Jun;56(3):243-7.

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