Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D06RCS
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| Former ID |
DCL001104
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| Drug Name |
Besonprodil
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| Synonyms |
Co 200461; PD 0196860; PD 196860; PD196860; Besonprodil (USAN); 2(3H)-Benzoxazolone, 6-((2-(4-((4-fluorophenyl)methyl)-1-piperidinyl)ethyl)sulfinyl); 6-(2-(4-(4-Fluorobenzyl)-piperidin-1-yl)-ethanesulfinyl)-3H-benzoxazol-2-one; 6-[2-[4-[(4-fluorophenyl)methyl]piperidin-1-yl]ethylsulfinyl]-3H-1,3-benzoxazol-2-one
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| Drug Type |
Small molecular drug
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| Indication | Parkinson's disease [ICD9: 332; ICD10:G20] | Discontinued in Phase 1 | [547173] | ||
| Therapeutic Class |
Neurodegenerative
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| Structure |
|
Download2D MOL |
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| Formula |
C21H23FN2O3S
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| Canonical SMILES |
C1CN(CCC1CC2=CC=C(C=C2)F)CCS(=O)C3=CC4=C(C=C3)NC(=O)O4
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| InChI |
1S/C21H23FN2O3S/c22-17-3-1-15(2-4-17)13-16-7-9-24(10-8-16)11-12-28(26)18-5-6-19-20(14-18)27-21(25)23-19/h1-6,14,16H,7-13H2,(H,23,25)
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| InChIKey |
FCBQJNCAKZSIAH-UHFFFAOYSA-N
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| CAS Number |
CAS 253450-09-8
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Glutamate [NMDA] receptor subunit epsilon 2 | Target Info | Antagonist | [536166] | |
| KEGG Pathway | Ras signaling pathway | ||||
| Rap1 signaling pathway | |||||
| cAMP signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Circadian entrainment | |||||
| Long-term potentiation | |||||
| Glutamatergic synapse | |||||
| Dopaminergic synapse | |||||
| Alzheimer's disease | |||||
| Amyotrophic lateral sclerosis (ALS) | |||||
| Huntington's disease | |||||
| Cocaine addiction | |||||
| Amphetamine addiction | |||||
| Nicotine addiction | |||||
| Alcoholism | |||||
| Systemic lupus erythematosus | |||||
| Pathway Interaction Database | ErbB4 signaling events | ||||
| Reelin signaling pathway | |||||
| References | |||||
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