Drug General Information
Drug ID	D06SYS
Former ID	DNC012050
Drug Name	METHYLNORADRENALINE
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[533545]
Structure		Download 2D MOL 3D MOL
Formula	C9H13NO3
Canonical SMILES	CC(C(C1=CC(=C(C=C1)O)O)O)N
InChI	1S/C9H13NO3/c1-5(10)9(13)6-2-3-7(11)8(12)4-6/h2-5,9,11-13H,10H2,1H3
InChIKey	GEFQWZLICWMTKF-UHFFFAOYSA-N
PubChem Compound ID	3917
Target and Pathway
Target(s)	Alpha-2A adrenergic receptor	Target Info	Inhibitor	[533545]
	Alpha-2B adrenergic receptor	Target Info	Inhibitor	[533545]
	Alpha-2C adrenergic receptor	Target Info	Inhibitor	[533545]
KEGG Pathway	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
PANTHER Pathway	Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome	Adrenoceptors
	Adrenaline signalling through Alpha-2 adrenergic receptor
	Adrenaline,noradrenaline inhibits insulin secretion
	G alpha (i) signalling events
	G alpha (z) signalling events
	Surfactant metabolismR-HSA-390696:Adrenoceptors
	G alpha (z) signalling eventsR-HSA-390696:Adrenoceptors
	Surfactant metabolism
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Platelet Aggregation (Plug Formation)
	Integration of energy metabolism
	GPCR ligand binding
	GPCR downstream signalingWP58:Monoamine GPCRs
	GPCR downstream signaling
References
Ref 533545	J Med Chem. 1982 Dec;25(12):1389-401.alpha 2 adrenoceptors: classification, localization, mechanisms, and targets for drugs.
Ref 533545	J Med Chem. 1982 Dec;25(12):1389-401.alpha 2 adrenoceptors: classification, localization, mechanisms, and targets for drugs.

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