Drug General Information
Drug ID	D06SZG
Former ID	DNC012463
Drug Name	6,7-Dichloro-3-hydroxy-1H-quinazoline-2,4-dione
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[527036]
Structure		Download 2D MOL 3D MOL
Formula	C8H4Cl2N2O3
Canonical SMILES	C1=C2C(=CC(=C1Cl)Cl)NC(=O)N(C2=O)O
InChI	1S/C8H4Cl2N2O3/c9-4-1-3-6(2-5(4)10)11-8(14)12(15)7(3)13/h1-2,15H,(H,11,14)
InChIKey	URXMQPMLTVUBON-UHFFFAOYSA-N
PubChem Compound ID	44315523
Target and Pathway
Target(s)	Glutamate [NMDA] receptor subunit epsilon 2	Target Info	Inhibitor	[527036]
	Glutamate [NMDA] receptor subunit epsilon 1	Target Info	Inhibitor	[527036]
	NMDA receptor subunit NR1	Target Info	Inhibitor	[527036]
KEGG Pathway	Ras signaling pathway
	Rap1 signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Circadian entrainment
	Long-term potentiation
	Glutamatergic synapse
	Dopaminergic synapse
	Alzheimer's disease
	Amyotrophic lateral sclerosis (ALS)
	Huntington's disease
	Cocaine addiction
	Amphetamine addiction
	Nicotine addiction
	Alcoholism
	Systemic lupus erythematosushsa04014:Ras signaling pathway
	Calcium signaling pathway
PANTHER Pathway	Huntington disease
	Ionotropic glutamate receptor pathway
	Metabotropic glutamate receptor group III pathway
	Metabotropic glutamate receptor group I pathway
	Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00029:Huntington disease
	Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Pathway Interaction Database	ErbB4 signaling events
	Reelin signaling pathwayreelinpathway:Reelin signaling pathway
Reactome	EPHB-mediated forward signaling
	Unblocking of NMDA receptor, glutamate binding and activation
	CREB phosphorylation through the activation of CaMKII
	Ras activation uopn Ca2+ infux through NMDA receptor
	RAF/MAP kinase cascadeR-HSA-438066:Unblocking of NMDA receptor, glutamate binding and activation
	RAF/MAP kinase cascadeR-HSA-3928662:EPHB-mediated forward signaling
	RAF/MAP kinase cascade
WikiPathways	Hypothetical Network for Drug Addiction
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	BDNF signaling pathwayWP666:Hypothetical Network for Drug Addiction
	Alzheimers DiseaseWP706:SIDS Susceptibility Pathways
	Spinal Cord Injury
	BDNF signaling pathway
	Alzheimers Disease
References
Ref 527036	Bioorg Med Chem Lett. 2004 May 3;14(9):2345-9.3-hydroxy-quinazoline-2,4-dione as a useful scaffold to obtain selective Gly/NMDA and AMPA receptor antagonists.
Ref 527036	Bioorg Med Chem Lett. 2004 May 3;14(9):2345-9.3-hydroxy-quinazoline-2,4-dione as a useful scaffold to obtain selective Gly/NMDA and AMPA receptor antagonists.

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