Drug General Information
Drug ID
D06VIP
Former ID
DNC005903
Drug Name
N-(tert-butoxycarbonyl)-valyl-glycine-nitrile
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527885]
Structure
Download
2D MOL

3D MOL

Formula
C12H21N3O3
Canonical SMILES
CC(C)C(C(=O)NCC#N)NC(=O)OC(C)(C)C
InChI
1S/C12H21N3O3/c1-8(2)9(10(16)14-7-6-13)15-11(17)18-12(3,4)5/h8-9H,7H2,1-5H3,(H,14,16)(H,15,17)/t9-/m0/s1
InChIKey
OHPJKVGJQUYVFQ-VIFPVBQESA-N
PubChem Compound ID
Target and Pathway
Target(s) Cathepsin S Target Info Inhibitor [527885]
Cathepsin L Target Info Inhibitor [527885]
Cathepsin K Target Info Inhibitor [527885]
KEGG Pathway Lysosome
Phagosome
Antigen processing and presentation
Tuberculosishsa04142:Lysosome
Proteoglycans in cancer
Rheumatoid arthritishsa04142:Lysosome
Osteoclast differentiation
Toll-like receptor signaling pathway
Rheumatoid arthritis
NetPath Pathway Leptin Signaling Pathway
IL2 Signaling PathwayNetPath_16:IL4 Signaling Pathway
TGF_beta_Receptor Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway
RANKL Signaling Pathway
IL2 Signaling Pathway
Reactome Endosomal/Vacuolar pathway
Degradation of the extracellular matrix
Trafficking and processing of endosomal TLR
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentationR-HSA-1236977:Endosomal/Vacuolar pathway
Collagen degradation
MHC class II antigen presentationR-HSA-1442490:Collagen degradation
Activation of Matrix Metalloproteinases
MHC class II antigen presentation
WikiPathways Class I MHC mediated antigen processing & presentation
Trafficking and processing of endosomal TLRWP2572:Primary Focal Segmental Glomerulosclerosis FSGSWP2018:RANKL/RANK Signaling Pathway
Osteoclast Signaling
References
Ref 527885J Med Chem. 2005 Dec 1;48(24):7688-707.Interaction of papain-like cysteine proteases with dipeptide-derived nitriles.
Ref 527885J Med Chem. 2005 Dec 1;48(24):7688-707.Interaction of papain-like cysteine proteases with dipeptide-derived nitriles.

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