Drug Information

Drug General Information
Drug ID
D06WJI
Former ID
DIB004209
Drug Name
OPC-28326
Synonyms
N-[2,6-Dimethyl-4-[4-[N-methyl-N-(2-phenylethyl)amino]piperidin-1-ylcarbonyl]phenyl]propionamide hydrochloride monohydrate
Drug Type
Small molecular drug
Indication Peripheral vascular disease [ICD9: 443.9; ICD10:I73.9] Discontinued in Phase 2 [546957]
Company
Otsuka America Pharmaceutical
Structure
Download
2D MOL

3D MOL
Formula
C26H36ClN3O2
Canonical SMILES
CCC(=O)NC1=C(C=C(C=C1C)C(=O)N2CCC(CC2)N(C)CCC3=CC=CC=C3<br />)C.Cl
InChI
1S/C26H35N3O2.ClH/c1-5-24(30)27-25-19(2)17-22(18-20(25)3)26(31)29-15-12-23(13-16-29)28(4)14-11-21-9-7-6-8-10-21;/h6-10,17-18,23H,5,11-16H2,1-4H3,(H,27,30);1H
InChIKey
ADNUSXMBYGPKTH-UHFFFAOYSA-N
PubChem Compound ID
219019
PubChem Substance ID
9374239, 14808966, 30422398, 76197694, 103837972, 113468407, 117561861, 126460070, 135134502, 137291123, 179293973, 233086179
Target and Pathway
Target(s) Alpha-1D adrenergic receptor Target Info Antagonist [525613]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretion
NetPath Pathway IL2 Signaling Pathway
Reactome Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 546957Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800011559)
Ref 525613Mechanisms of action of OPC-28326, a selective hindlimb vasodilator. J Pharmacol Exp Ther. 1999 Nov;291(2):604-11.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.