Drug Information

Drug General Information
Drug ID
D06WLB
Former ID
DNC003798
Drug Name
Benzyl-[2-(1H-indol-4-yloxy)-ethyl]-amine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [525599]
Structure
Download
2D MOL

3D MOL
Formula
C17H18N2O
Canonical SMILES
C1=CC=C(C=C1)CNCCOC2=CC=CC3=C2C=CN3
InChI
1S/C17H18N2O/c1-2-5-14(6-3-1)13-18-11-12-20-17-8-4-7-16-15(17)9-10-19-16/h1-10,18-19H,11-13H2
InChIKey
ZEHDEZWEFBOGNZ-UHFFFAOYSA-N
PubChem Compound ID
9838216
Target and Pathway
Target(s) D(2) dopamine receptor Target Info Inhibitor [525599]
D(4) dopamine receptor Target Info Inhibitor [525599]
D(3) dopamine receptor Target Info Inhibitor [525599]
KEGG Pathway Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholismhsa04080:Neuroactive ligand-receptor interaction
Dopaminergic synapsehsa04080:Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic NeuronsWP666:Hypothetical Network for Drug Addiction
Nicotine Activity on Dopaminergic Neurons
GPCRs, OtherWP58:Monoamine GPCRs
GPCRs, Other
References
Ref 525599Bioorg Med Chem Lett. 1999 Sep 6;9(17):2593-8.New generation dopaminergic agents. 7. Heterocyclic bioisosteres that exploit the 3-OH-phenoxyethylamine D2 template.
Ref 525599Bioorg Med Chem Lett. 1999 Sep 6;9(17):2593-8.New generation dopaminergic agents. 7. Heterocyclic bioisosteres that exploit the 3-OH-phenoxyethylamine D2 template.

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