Drug Information

Drug General Information
Drug ID
D07BTU
Former ID
DNC004315
Drug Name
6-Benzyloxy-5-nitro-pyrimidine-2,4-diamine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [534565]
Structure
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2D MOL

3D MOL
Formula
C11H11N5O3
Canonical SMILES
C1=CC=C(C=C1)COC2=NC(=NC(=C2[N+](=O)[O-])N)N
InChI
1S/C11H11N5O3/c12-9-8(16(17)18)10(15-11(13)14-9)19-6-7-4-2-1-3-5-7/h1-5H,6H2,(H4,12,13,14,15)
InChIKey
VLVHHGNPHBVEIG-UHFFFAOYSA-N
PubChem Compound ID
9860003
Target and Pathway
Target(s) Methylated-DNA--protein-cysteine methyltransferase Target Info Inhibitor [534565]
WikiPathways DNA Damage Reversal
References
Ref 534565J Med Chem. 1998 Feb 12;41(4):503-8.Inhibition of human O6-alkylguanine-DNA alkyltransferase and potentiation of the cytotoxicity of chloroethylnitrosourea by 4(6)-(benzyloxy)-2,6(4)-diamino-5-(nitroor nitroso)pyrimidine derivatives and analogues.
Ref 534565J Med Chem. 1998 Feb 12;41(4):503-8.Inhibition of human O6-alkylguanine-DNA alkyltransferase and potentiation of the cytotoxicity of chloroethylnitrosourea by 4(6)-(benzyloxy)-2,6(4)-diamino-5-(nitroor nitroso)pyrimidine derivatives and analogues.

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