Drug General Information
Drug ID
D07CEU
Former ID
DNC014385
Drug Name
SOPHORICOSIDE
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551217]
Structure
Download
2D MOL

3D MOL

Formula
C21H20O10
Canonical SMILES
C1=CC(=CC=C1C2=COC3=CC(=CC(=C3C2=O)O)O)OC4C(C(C(C(O4)CO<br />)O)O)O
InChI
1S/C21H20O10/c22-7-15-18(26)19(27)20(28)21(31-15)30-11-3-1-9(2-4-11)12-8-29-14-6-10(23)5-13(24)16(14)17(12)25/h1-6,8,15,18-24,26-28H,7H2/t15-,18-,19+,20-,21-/m1/s1
InChIKey
ISQRJFLLIDGZEP-CMWLGVBASA-N
PubChem Compound ID
Target and Pathway
Target(s) Interleukin-5 Target Info Inhibitor [551217]
KEGG Pathway Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
Hematopoietic cell lineage
T cell receptor signaling pathway
Fc epsilon RI signaling pathway
Intestinal immune network for IgA production
Asthma
Autoimmune thyroid disease
Inflammatory bowel disease (IBD)
Allograft rejection
NetPath Pathway TCR Signaling Pathway
IL2 Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway Interleukin signaling pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
IL4-mediated signaling events
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Glucocorticoid receptor regulatory network
IL5-mediated signaling events
AP-1 transcription factor network
PathWhiz Pathway Fc Epsilon Receptor I Signaling in Mast Cells
Reactome GPVI-mediated activation cascade
G beta:gamma signalling through PI3Kgamma
Interleukin-3, 5 and GM-CSF signaling
RAF/MAP kinase cascade
Interleukin receptor SHC signaling
WikiPathways Cytokines and Inflammatory Response
Inflammatory Response Pathway
Hematopoietic Stem Cell Differentiation
Interleukin-2 signaling
Allograft Rejection
Interleukin-3, 5 and GM-CSF signaling
References
Ref 551217Design and synthesis of novel hydroxyalkylaminomethylchromones for their IL-5 inhibitory activity. Bioorg Med Chem. 2010 Jul 1;18(13):4625-9. doi: 10.1016/j.bmc.2010.05.028. Epub 2010 May 15.
Ref 551217Design and synthesis of novel hydroxyalkylaminomethylchromones for their IL-5 inhibitory activity. Bioorg Med Chem. 2010 Jul 1;18(13):4625-9. doi: 10.1016/j.bmc.2010.05.028. Epub 2010 May 15.

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