Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D07DNV
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| Former ID |
DIB007457
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| Drug Name |
ARN-2966
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| Synonyms |
ARN-2966; ARN-4261; Abeta aggregation inhibitors (Alzheimer's disease); Abeta aggregation inhibitors (Alzheimer's disease), New York University/Aria Neurosciences
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| Drug Type |
Small molecular drug
|
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| Indication | Alzheimer disease [ICD9: 331; ICD10:G30] | Investigative | [542536] | ||
| Company |
New York University
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| Structure |
|
Download2D MOL |
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| Formula |
C12H12N2O
|
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| InChI |
InChI=1S/C12H12N2O/c15-12-7-2-1-6-11(12)14-9-10-5-3-4-8-13-10/h1-8,14-15H,9H2
|
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| InChIKey |
GXJRVWZNMZGWAQ-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Amyloid beta A4 protein | Target Info | Inhibitor | [543619] | |
| KEGG Pathway | Notch signaling pathway | ||||
| Alzheimer's disease | |||||
| Reactome | Nuclear signaling by ERBB4 | ||||
| Degradation of the extracellular matrix | |||||
| Regulated proteolysis of p75NTR | |||||
| NRIF signals cell death from the nucleus | |||||
| Activated NOTCH1 Transmits Signal to the Nucleus | |||||
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | |||||
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | |||||
| EPH-ephrin mediated repulsion of cells | |||||
| References | |||||
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