TTD | Drug: D07DQO

Drug General Information
Drug ID	D07DQO
Former ID	DNC009567
Drug Name	N-(6-phenoxypyridin-3-yl)-1H-indole-3-carboxamide
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529582]
Structure		Download 2D MOL 3D MOL
Formula	C20H15N3O2
Canonical SMILES	C1=CC=C(C=C1)OC2=NC=C(C=C2)NC(=O)C3=CNC4=CC=CC=C43
InChI	1S/C20H15N3O2/c24-20(17-13-21-18-9-5-4-8-16(17)18)23-14-10-11-19(22-12-14)25-15-6-2-1-3-7-15/h1-13,21H,(H,23,24)
InChIKey	KBQZTNRCKHEJQM-UHFFFAOYSA-N
PubChem Compound ID	44250365
Target and Pathway
Target(s)	5-hydroxytryptamine 2C receptor	Target Info	Inhibitor	[529582]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Serotonergic synapse
	Inflammatory mediator regulation of TRP channels
PANTHER Pathway	5HT2 type receptor mediated signaling pathway
Reactome	Serotonin receptors
Reactome	G alpha (q) signalling events
WikiPathways	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 529582	Bioorg Med Chem Lett. 2008 Jul 15;18(14):3844-7. Epub 2008 Jun 21.Synthesis and structure-activity relationship of 1H-indole-3-carboxylic acid pyridine-3-ylamides: a novel series of 5-HT2C receptor antagonists.
Ref 529582	Bioorg Med Chem Lett. 2008 Jul 15;18(14):3844-7. Epub 2008 Jun 21.Synthesis and structure-activity relationship of 1H-indole-3-carboxylic acid pyridine-3-ylamides: a novel series of 5-HT2C receptor antagonists.

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Drug Information