Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D07GBV
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| Former ID |
DNC003983
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| Drug Name |
3-(1-Phenethyl-piperidin-4-yl)-2-phenyl-1H-indole
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [525940] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C27H28N2
|
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| Canonical SMILES |
C1CN(CCC1C2=C(NC3=CC=CC=C32)C4=CC=CC=C4)CCC5=CC=CC=C5
|
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| InChI |
1S/C27H28N2/c1-3-9-21(10-4-1)15-18-29-19-16-22(17-20-29)26-24-13-7-8-14-25(24)28-27(26)23-11-5-2-6-12-23/h1-14,22,28H,15-20H2
|
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| InChIKey |
MONKRYYJEIHBRU-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Potassium voltage-gated channel subfamily H member 2 | Target Info | Inhibitor | [526043] | |
| 5-hydroxytryptamine 2A receptor | Target Info | Inhibitor | [525940] | ||
| PANTHER Pathway | 5HT2 type receptor mediated signaling pathway | ||||
| PathWhiz Pathway | Muscle/Heart Contraction | ||||
| WikiPathways | SIDS Susceptibility Pathways | ||||
| Hematopoietic Stem Cell Differentiation | |||||
| Potassium ChannelsWP733:Serotonin Receptor 2 and STAT3 Signaling | |||||
| Serotonin Receptor 2 and ELK-SRF/GATA4 signaling | |||||
| Monoamine GPCRs | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| GPCRs, Other | |||||
| References | |||||
| Ref 525940 | Bioorg Med Chem Lett. 2000 Dec 18;10(24):2701-3.3-(4-Piperidinyl)- and 3-(8-aza-bicyclo[3.2.1]oct-3-yl)-2-phenyl-1H-indoles as bioavailable h5-HT2A antagonists. | ||||
| Ref 526043 | J Med Chem. 2001 May 10;44(10):1603-14.3-(4-Fluoropiperidin-3-yl)-2-phenylindoles as high affinity, selective, and orally bioavailable h5-HT(2A) receptor antagonists. | ||||
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