Drug Information

Drug General Information
Drug ID
D07HGR
Former ID
DAP000587
Drug Name
Lisinopril
Synonyms
Acerbon; Acercomp; Alapril; Carace; Cipral; Cipril; Coric; Doneka; Inhibril; Inopril; LPR; Linopril; Linvas; Lipril; Lisinal; Lisinoprilum; Lisipril; Lisoril; Lispril; Longes; Loril; Lysinopril; Noperten; Novatec; Presiten; Prinil; Prinivil; Sinopril; Sinopryl; Tensopril; Tensyn; Tersif; Vivatec; Zestril; Lisinopril anhydrous; Lisinoprilum [Latin]; MK 521; MK 522; Hipril (TN); Lisinopril (INN); Lisinopril (anhydrous); MK-521; Prinivil (TN); Tensopril (TN); Zestril (TN); N-(1(S)-Carboxy-3-phenylpropyl)-L-lysyl-L-proline; N2-[(1S)-1-carboxy-3-phenylpropyl]-L-lysyl-L-proline; [N2-[(S)-1-CARBOXY-3-PHENYLPROPYL]-L-LYSYL-L-PROLINE; N(2)-[(1S)-1-carboxy-3-phenylpropyl]-L-lysyl-L-proline; N2-((S)-1-Carboxy-3-phenylpropyl)-L-lysyl-L-proline; (2S)-1-[(2S)-6-amino-2-[[(2S)-1-hydroxy-1-oxo-4-phenylbutan-2-yl]amino]hexanoyl]pyrrolidine-2-carboxylic acid; (S)-1-(N(2)-(1-carboxy-3-phenylpropyl)-L-lysyl)-L-proline; (S)-1-(N(sup 2)-(1-Carboxy-3-phenylpropyl)-L-lysyl)-L-proline; (S)-1-(N2-(1-Carboxy-3-phenylpropyl)-L-lysyl)-L-proline; 1-(N2-(1-Carboxy-3-phenylpropyl)-L-lysyl)-L-proline; 1-[Nalpha-[(S)-1-Carboxy-3-phenylpropyl]-L-lysyl]-L-proline
Drug Type
Small molecular drug
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Approved [536361], [541501]
Therapeutic Class
Antihypertensive Agents
Company
Merck & Co
Structure
Download
2D MOL

3D MOL
Formula
C21H31N3O5
InChI
InChI=1S/C21H31N3O5/c22-13-5-4-9-16(19(25)24-14-6-10-18(24)21(28)29)23-17(20(26)27)12-11-15-7-2-1-3-8-15/h1-3,7-8,16-18,23H,4-6,9-14,22H2,(H,26,27)(H,28,29)/t16-,17-,18-/m0/s1
InChIKey
RLAWWYSOJDYHDC-BZSNNMDCSA-N
CAS Number
CAS 83915-83-7
PubChem Compound ID
5362119
PubChem Substance ID
7888691, 7979780, 8149783, 10322439, 11336212, 11361451, 11363391, 11365953, 11368515, 11372101, 11374737, 11376677, 11462423, 11466329, 11467449, 11485087, 11486217, 11489272, 11490756, 11492854, 11494311, 11654003, 12013163, 14806092, 14830773, 25622282, 26612244, 26680616, 26697064, 39384398, 46504893, 47515403, 47515404, 47810844, 47885506, 47885507, 48035230, 49698425, 49835323, 50019882, 50085996, 50124344, 53787084, 56311259, 57362085, 78195378, 81066263, 85787499, 87560323, 92124278
ChEBI ID
ChEBI:6503
SuperDrug ATC ID
C09AA03
SuperDrug CAS ID
cas=083915837
Target and Pathway
Target(s) Angiotensin-converting enzyme Target Info Inhibitor [537530]
KEGG Pathway Renin-angiotensin system
Chagas disease (American trypanosomiasis)
Hypertrophic cardiomyopathy (HCM)
PathWhiz Pathway Angiotensin Metabolism
Reactome Metabolism of Angiotensinogen to Angiotensins
WikiPathways ACE Inhibitor Pathway
Metabolism of Angiotensinogen to Angiotensins
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 541501(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6360).
Ref 537530Involvement of vascular angiotensin II-forming enzymes in the progression of aortic abdominal aneurysms in angiotensin II- infused ApoE-deficient mice. J Atheroscler Thromb. 2009 Jun;16(3):164-71. Epub 2009 Jun 25.

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