Drug General Information
Drug ID	D07HXL
Former ID	DNC004139
Drug Name	PD-81723
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529655]
Structure		Download 2D MOL 3D MOL
Formula	C14H12F3NOS
Canonical SMILES	CC1=C(SC(=C1C(=O)C2=CC(=CC=C2)C(F)(F)F)N)C
InChI	1S/C14H12F3NOS/c1-7-8(2)20-13(18)11(7)12(19)9-4-3-5-10(6-9)14(15,16)17/h3-6H,18H2,1-2H3
InChIKey	KKDKAWKYGCUOGR-UHFFFAOYSA-N
PubChem Compound ID	122028
Target and Pathway
Target(s)	Adenosine A1 receptor	Target Info	Inhibitor	[529655]
KEGG Pathway	cGMP-PKG signaling pathway
	cAMP signaling pathway
	Sphingolipid signaling pathway
	Neuroactive ligand-receptor interaction
	Morphine addiction
NetPath Pathway	TCR Signaling Pathway
	RANKL Signaling Pathway
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome	Adenosine P1 receptors
	G alpha (i) signalling events
WikiPathways	Nucleotide GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 529655	J Med Chem. 2008 Sep 25;51(18):5875-9. Epub 2008 Aug 26.Synthesis and biological evaluation of 2-amino-3-(4-chlorobenzoyl)-4-[N-(substituted) piperazin-1-yl]thiophenes as potent allosteric enhancersof the A1 adenosine receptor.
Ref 529655	J Med Chem. 2008 Sep 25;51(18):5875-9. Epub 2008 Aug 26.Synthesis and biological evaluation of 2-amino-3-(4-chlorobenzoyl)-4-[N-(substituted) piperazin-1-yl]thiophenes as potent allosteric enhancersof the A1 adenosine receptor.

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