Drug Information

Drug General Information
Drug ID
D07INV
Former ID
DAP000598
Drug Name
Ethoxzolamide
Synonyms
Cardrase; EZL; Ethamide; Ethoxazolamide; Ethoxyzolamide; Etoxzolamide; Glaucotensil; Mingoral; Redupresin; Diuretic C; Cardrase (TN); Ethoxzolamide (EZA); U-4191; 6-(ethyloxy)-1,3-benzothiazole-2-sulfonamide; 6-Ethoxy-1,3-benzothiazole-2-sulfonamide; 6-Ethoxy-2-benzothiazolesulfonamide; 6-Ethoxy-benzothiazole-2-sulfonic acid amide; 6-Ethoxybenzo[d]thiazole-2-sulfonamide; 6-Ethoxybenzothiazole-2-sulfonamide; 6-Ethoxybenzothiazole-2-sulphonamide; 6-Ethoxyzolamide
Drug Type
Small molecular drug
Indication Glaucoma; Duodenal ulcers [ICD9: 365, 531-534; ICD10:H40-H42, K25-K27] Approved [538442], [541896]
Therapeutic Class
Diuretics
Structure
Download
2D MOL

3D MOL
Formula
C9H10N2O3S2
InChI
InChI=1S/C9H10N2O3S2/c1-2-14-6-3-4-7-8(5-6)15-9(11-7)16(10,12)13/h3-5H,2H2,1H3,(H2,10,12,13)
InChIKey
OUZWUKMCLIBBOG-UHFFFAOYSA-N
CAS Number
CAS 452-35-7
PubChem Compound ID
3295
PubChem Substance ID
75836, 840267, 855751, 893338, 5242023, 7849499, 8152095, 10523205, 15213608, 24860121, 29215007, 29222433, 46509023, 46511452, 48415980, 49681475, 49890761, 50100966, 56422188, 57280084, 57280086, 57288316, 57304388, 57321712, 80657483, 85176911, 85306595, 87557627, 92308013, 92308213, 92729651, 95614375, 96021935, 99444198, 103048393, 103164710, 104171380, 104303092, 124587685, 124800633, 124883557, 124883558, 124897844, 125637519, 126671832, 128865742, 134337889, 134975323, 135378086, 137004941
Target and Pathway
Target(s) Carbonic anhydrase I Target Info Modulator [556264]
KEGG Pathway Nitrogen metabolism
Pathway Interaction Database C-MYB transcription factor network
PathWhiz Pathway Gastric Acid Production
Reactome Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Reversible hydration of carbon dioxide
WikiPathways Reversible Hydration of Carbon Dioxide
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
References
Ref 538442FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 011047.
Ref 541896(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6814).
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

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