Drug General Information
Drug ID	D07JMN
Former ID	DNC009124
Drug Name	1-(pyridin-2-yl)piperazine
Synonyms	1-Pyridin-2-yl-piperazine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[533509]
Structure		Download 2D MOL 3D MOL
Formula	C9H13N3
Canonical SMILES	C1CN(CCN1)C2=CC=CC=N2
InChI	1S/C9H13N3/c1-2-4-11-9(3-1)12-7-5-10-6-8-12/h1-4,10H,5-8H2
InChIKey	GZRKXKUVVPSREJ-UHFFFAOYSA-N
PubChem Compound ID	94459
Target and Pathway
Target(s)	Phospholipase D1	Target Info	Inhibitor	[530029]
	Alpha-2A adrenergic receptor	Target Info	Inhibitor	[533509]
	Alpha-1D adrenergic receptor	Target Info	Inhibitor	[533509]
	Alpha-1A adrenergic receptor	Target Info	Inhibitor	[533509]
	Alpha-2B adrenergic receptor	Target Info	Inhibitor	[533509]
BioCyc Pathway	Phospholipases
KEGG Pathway	Glycerophospholipid metabolism
	Ether lipid metabolism
	Metabolic pathways
	Ras signaling pathway
	cAMP signaling pathway
	Sphingolipid signaling pathway
	Endocytosis
	Fc gamma R-mediated phagocytosis
	Glutamatergic synapse
	GnRH signaling pathway
	Pathways in cancer
	Pancreatic cancer
	Choline metabolism in cancerhsa04022:cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
	Adrenergic signaling in cardiomyocytes
	Vascular smooth muscle contraction
	Salivary secretionhsa04020:Calcium signaling pathway
	AMPK signaling pathway
	Salivary secretionhsa04022:cGMP-PKG signaling pathway
NetPath Pathway	IL2 Signaling Pathway
PANTHER Pathway	Angiogenesis
	Ras PathwayP00002:Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Pathway Interaction Database	RhoA signaling pathway
	Arf6 trafficking events
	CDC42 signaling events
	Arf6 downstream pathway
	mTOR signaling pathway
	ErbB1 downstream signaling
	IL8- and CXCR1-mediated signaling events
	Alpha-synuclein signaling
Reactome	Role of phospholipids in phagocytosisR-HSA-390696:Adrenoceptors
	Adrenaline signalling through Alpha-2 adrenergic receptor
	Adrenaline,noradrenaline inhibits insulin secretion
	G alpha (i) signalling events
	G alpha (z) signalling events
	Surfactant metabolismR-HSA-390696:Adrenoceptors
	G alpha (q) signalling events
	G alpha (12/13) signalling eventsR-HSA-390696:Adrenoceptors
WikiPathways	EGF/EGFR Signaling Pathway
	TSH signaling pathwayWP58:Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Platelet Aggregation (Plug Formation)
	Integration of energy metabolism
	GPCR ligand binding
	GPCR downstream signalingWP58:Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR downstream signaling
	GPCRs, OtherWP58:Monoamine GPCRs
	Endothelin Pathways
	AMPK SignalingWP58:Monoamine GPCRs
References
Ref 533509	J Med Chem. 1984 Sep;27(9):1182-5.Adrenoceptor and tetrabenazine antagonism activities of some pyridinyltetrahydropyridines.
Ref 530029	Bioorg Med Chem Lett. 2009 Apr 15;19(8):2240-3. Epub 2009 Mar 6.Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part II. Identification of the 1,3,8-triazaspiro[4,5]decan-4-one privileged structure that engenders PLD2 selectivity.
Ref 533509	J Med Chem. 1984 Sep;27(9):1182-5.Adrenoceptor and tetrabenazine antagonism activities of some pyridinyltetrahydropyridines.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.