Drug Information

Drug General Information
Drug ID
D07KYT
Former ID
DNCL002109
Drug Name
AC220
Synonyms
Quizartinib
Drug Type
Small molecular drug
Indication Leukemia [ICD9: 208.9; ICD10:C90-C95] Phase 3 [524603]
Company
Ambit Biosciences; Astellas Pharma US
Structure
Download
2D MOL

3D MOL
Formula
C29H32N6O4S
Canonical SMILES
CC(C)(C)C1=CC(=NO1)NC(=O)NC2=CC=C(C=C2)C3=CN4C5=C(C=C(C<br />=C5)OCCN6CCOCC6)SC4=N3
InChI
1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22-18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4-9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36)
InChIKey
CVWXJKQAOSCOAB-UHFFFAOYSA-N
PubChem Compound ID
24889392
PubChem Substance ID
51081888, 57459864, 99437205, 103699058, 104155051, 124757317, 124950695, 125164121, 125329937, 135264521, 135626680, 135685330, 135685331, 135685350, 135686086, 135686087, 135686104, 135686105, 135727410, 135727821, 136350019, 136367457, 136368137, 136920258, 137262639, 137275856, 141168277, 144115531, 152030976, 152258408, 160647245, 162011412, 162037647, 162189542, 163775377, 164777892, 174561046, 177749071, 178102286, 180371638, 188899552, 196409687, 198974101, 223705253, 224646788, 226453032, 243160980, 249814511, 249818724, 249869565
Drug Resistance Mutation (DRM)
DRM DRM Info
References
Ref 524603ClinicalTrials.gov (NCT02039726) An Open-label Study of Quizartinib Monotherapy vs. Salvage Chemotherapy in Acute Myeloid Leukemia (AML) Subjects. U.S. National Institutes of Health.

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