Drug General Information
Drug ID
D07LFZ
Former ID
DNC006302
Drug Name
4-(5-(4-aminophenyl)thiophen-2-yl)benzenamine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527907]
Structure
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2D MOL

3D MOL

Formula
C16H14N2S
Canonical SMILES
C1=CC(=CC=C1C2=CC=C(S2)C3=CC=C(C=C3)N)N
InChI
1S/C16H14N2S/c17-13-5-1-11(2-6-13)15-9-10-16(19-15)12-3-7-14(18)8-4-12/h1-10H,17-18H2
InChIKey
QUVIYFJRWXKEKM-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) Amyloid beta A4 protein Target Info Inhibitor [527907]
KEGG Pathway Notch signaling pathway
Alzheimer's disease
Reactome Nuclear signaling by ERBB4
Degradation of the extracellular matrix
Regulated proteolysis of p75NTR
NRIF signals cell death from the nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
EPH-ephrin mediated repulsion of cells
WikiPathways Notch Signaling Pathway
Signaling by ERBB4
Signaling by NOTCH3
Signaling by NOTCH4
Signaling by NOTCH1
Signaling by NOTCH2
Notch Signaling Pathway
Alzheimers Disease
Signalling by NGF
References
Ref 527907Bioorg Med Chem Lett. 2006 Mar 1;16(5):1350-2. Epub 2005 Dec 1.Design, synthesis, and structure-activity relationship of novel thiophene derivatives for beta-amyloid plaque imaging.
Ref 527907Bioorg Med Chem Lett. 2006 Mar 1;16(5):1350-2. Epub 2005 Dec 1.Design, synthesis, and structure-activity relationship of novel thiophene derivatives for beta-amyloid plaque imaging.

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