Drug Information

Drug General Information
Drug ID
D07LRJ
Former ID
DNC003657
Drug Name
SB-271046
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539805]
Structure
Download
2D MOL

3D MOL
Formula
C20H22ClN3O3S2
InChI
InChI=1S/C20H22ClN3O3S2/c1-13-16-11-14(21)3-6-19(16)28-20(13)29(25,26)23-15-4-5-18(27-2)17(12-15)24-9-7-22-8-10-24/h3-6,11-12,22-23H,7-10H2,1-2H3
InChIKey
LOCQRDBFWSXQQI-UHFFFAOYSA-N
PubChem Compound ID
5312149
PubChem Substance ID
7980575, 11056907, 14906583, 39341767, 47285909, 48329098, 53338758, 57359529, 58097771, 85209290, 103199108, 103988997, 114158005, 126522428, 128517213, 131549286, 134340862, 135651001, 142034489, 162009826, 162223692, 164024753, 172914471, 186000965, 226553455, 252473346
Target and Pathway
Target(s) D(3) dopamine receptor Target Info Inhibitor [529191]
5-hydroxytryptamine 6 receptor Target Info Inhibitor [530058]
Dopamine D1 receptor Target Info Inhibitor [529191]
5-hydroxytryptamine 2A receptor Target Info Inhibitor [529191]
5-hydroxytryptamine 1A receptor Target Info Inhibitor [529191]
D(4) dopamine receptor Target Info Inhibitor [529191]
5-hydroxytryptamine 7 receptor Target Info Inhibitor [529191]
D(2) dopamine receptor Target Info Inhibitor [529191]
5-hydroxytryptamine 2C receptor Target Info Inhibitor [529191]
KEGG Pathway Neuroactive ligand-receptor interaction
Dopaminergic synapsehsa04020:Calcium signaling pathway
cAMP signaling pathway
Serotonergic synapsehsa04020:Calcium signaling pathway
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Amphetamine addiction
Morphine addiction
Alcoholismhsa04020:Calcium signaling pathway
Serotonergic synapse
Inflammatory mediator regulation of TRP channelshsa04024:cAMP signaling pathway
Serotonergic synapsehsa04080:Neuroactive ligand-receptor interaction
Dopaminergic synapsehsa04014:Ras signaling pathway
Calcium signaling pathway
Serotonergic synapsehsa04015:Rap1 signaling pathway
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP05912:Dopamine receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Nicotine pharmacodynamics pathwayP04374:5HT2 type receptor mediated signaling pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 6 and SerotoninPW000440:Dopamine Activation of Neurological Reward SystemPW000443:Excitatory Neural Signalling Through 5-HTR 7 and Serotonin
Reactome Dopamine receptors
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (s) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (s) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
GPCRs, OtherWP734:Serotonin Receptor 4/6/7 and NR3C Signaling
GPCR downstream signalingWP666:Hypothetical Network for Drug Addiction
Genes and (Common) Pathways Underlying Drug Addiction
GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
Gastrin-CREB signalling pathway via PKC and MAPK
GPCRs, OtherWP722:Serotonin HTR1 Group and FOS Pathway
GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
Nicotine Activity on Dopaminergic NeuronsWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
References
Ref 539805(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 276).
Ref 529191Bioorg Med Chem Lett. 2008 Jan 15;18(2):738-43. Epub 2007 Nov 17.Discovery of 3-aryl-3-methyl-1H-quinoline-2,4-diones as a new class of selective 5-HT6 receptor antagonists.
Ref 530058Bioorg Med Chem Lett. 2009 May 1;19(9):2409-12. Epub 2009 Mar 25.Synthesis and SAR of tolylamine 5-HT6 antagonists.

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