Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D07LUJ
|
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| Former ID |
DNC007423
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| Drug Name |
URSOLIC ACID
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [530285] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C30H48O3
|
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| Canonical SMILES |
CC1CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(C5(C)C)O)C)C)C2C1C)C)<br />C(=O)O
|
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| InChI |
1S/C30H48O3/c1-18-10-15-30(25(32)33)17-16-28(6)20(24(30)19(18)2)8-9-22-27(5)13-12-23(31)26(3,4)21(27)11-14-29(22,28)7/h8,18-19,21-24,31H,9-17H2,1-7H3,(H,32,33)/t18-,19+,21+,22-,23+,24+,27+,28-,29-,30+/m1/s1
|
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| InChIKey |
WCGUUGGRBIKTOS-GPOJBZKASA-N
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Corticosteroid 11-beta-dehydrogenase, isozyme 1 | Target Info | Inhibitor | [530656] | |
| Phospholipase A2 | Target Info | Inhibitor | [527616] | ||
| DNA polymerase | Target Info | Inhibitor | [525684] | ||
| Glycogen phosphorylase, muscle form | Target Info | Inhibitor | [530285] | ||
| mRNA of Protein tyrosine phosphatase-1B | Target Info | Inhibitor | [530454] | ||
| BioCyc Pathway | PhospholipasesPWY-5941:Glycogenolysis | ||||
| KEGG Pathway | Steroid hormone biosynthesis | ||||
| Metabolism of xenobiotics by cytochrome P450 | |||||
| Metabolic pathways | |||||
| Chemical carcinogenesishsa00564:Glycerophospholipid metabolism | |||||
| Ether lipid metabolism | |||||
| Arachidonic acid metabolism | |||||
| Linoleic acid metabolism | |||||
| alpha-Linolenic acid metabolism | |||||
| Ras signaling pathway | |||||
| Vascular smooth muscle contraction | |||||
| Pancreatic secretion | |||||
| Fat digestion and absorptionhsa00500:Starch and sucrose metabolism | |||||
| Insulin signaling pathway | |||||
| Glucagon signaling pathwayhsa04520:Adherens junction | |||||
| Pathway Interaction Database | Fc-epsilon receptor I signaling in mast cellsinsulin_pathway:Insulin Pathway | ||||
| Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) | |||||
| Signaling events mediated by PTP1B | |||||
| Calcineurin-regulated NFAT-dependent transcription in lymphocytes | |||||
| Signaling events mediated by TCPTP | |||||
| IGF1 pathway | |||||
| EGF receptor (ErbB1) signaling pathway | |||||
| Posttranslational regulation of adherens junction stability and dissassembly | |||||
| PDGFR-beta signaling pathway | |||||
| N-cadherin signaling events | |||||
| PathWhiz Pathway | Steroidogenesis | ||||
| WikiPathways | Prostaglandin Synthesis and Regulation | ||||
| Metabolism of steroid hormones and vitamin D | |||||
| Glucocorticoid & Mineralcorticoid MetabolismWP2740:Glycerophospholipid biosynthesisWP500:Glycogen Metabolism | |||||
| Metabolism of carbohydratesWP481:Insulin Signaling | |||||
| Growth hormone receptor signaling | |||||
| Leptin signaling pathway | |||||
| Interferon gamma signaling | |||||
| Interferon alpha/beta signaling | |||||
| Integrin alphaIIb beta3 signaling | |||||
| References | |||||
| Ref 525684 | J Nat Prod. 1999 Dec;62(12):1624-6.DNA polymerase beta inhibitors from Baeckea gunniana. | ||||
| Ref 527616 | Bioorg Med Chem Lett. 2005 Sep 15;15(18):4100-4.Synthesis of benzoyl phenyl benzoates as effective inhibitors for phospholipase A2 and hyaluronidase enzymes. | ||||
| Ref 530285 | J Nat Prod. 2009 Aug;72(8):1414-8.Synthesis of 3-deoxypentacyclic triterpene derivatives as inhibitors of glycogen phosphorylase. | ||||
| Ref 530454 | Bioorg Med Chem Lett. 2009 Dec 1;19(23):6745-9. Epub 2009 Oct 1.Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica. | ||||
| Ref 530656 | Bioorg Med Chem. 2010 Feb 15;18(4):1507-15. Epub 2010 Jan 11.11beta-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational approaches. | ||||
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