Drug Information

Drug General Information
Drug ID
D07LUR
Former ID
DNC002440
Drug Name
Alpha-D-Mannose
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551393]
Structure
Download
2D MOL

3D MOL
Formula
C6H12O6
Canonical SMILES
C(C1C(C(C(C(O1)O)O)O)O)O
InChI
1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5+,6+/m1/s1
InChIKey
WQZGKKKJIJFFOK-PQMKYFCFSA-N
CAS Number
CAS 3458-28-4
PubChem Compound ID
185698
PubChem Substance ID
4188, 584309, 584577, 585323, 585890, 818886, 819860, 820291, 820631, 820632, 820633, 820923, 821116, 821332, 821413, 821424, 821447, 821561, 821794, 821798, 821933, 821940, 821956, 821963, 822552, 822575, 822586, 822746, 822775, 822831, 823017, 823023, 823058, 823092, 824133, 824135, 824229, 825243, 825244, 825245, 825293, 825294, 825295, 825297, 825440, 825444, 825448, 825898, 826257, 827093
Target and Pathway
Target(s) ADAM 33 Target Info Inhibitor [551393]
Liver carboxylesterase Target Info Inhibitor [551393]
Lactotransferrin Target Info Inhibitor [551393]
Reticulon 4 receptor Target Info Inhibitor [551393]
Neuraminidase Target Info Inhibitor [551393]
Cytotoxic T-lymphocyte protein 4 Target Info Inhibitor [551393]
Antithrombin-III Target Info Inhibitor [551393]
Glycoprotein hormones alpha chain Target Info Inhibitor [551393]
Phospholipase A2 Target Info Inhibitor [551393]
Rhodopsin Target Info Inhibitor [551393]
Insulin-like growth factor I receptor Target Info Inhibitor [551393]
Alpha-galactosidase A Target Info Inhibitor [551393]
Prostaglandin G/H synthase 1 Target Info Inhibitor [551393]
Interleukin-6 receptor Target Info Inhibitor [551393]
Low-density lipoprotein receptor Target Info Inhibitor [551393]
Heparin cofactor II Target Info Inhibitor [551393]
Hemagglutinin Target Info Inhibitor [551393]
Beta-2-glycoprotein 1 Target Info Inhibitor [551393]
Cathepsin D Target Info Inhibitor [551393]
Dipeptidyl peptidase IV Target Info Inhibitor [551393]
Lactase-phlorizin hydrolase Target Info Inhibitor [551393]
T-cell surface antigen CD2 Target Info Inhibitor [551393]
Cholinesterase Target Info Inhibitor [551393]
Nitric-oxide synthase, brain Target Info Inhibitor [551393]
Deoxyribonuclease I Target Info Inhibitor [551393]
High affinity immunoglobulin epsilon receptor Target Info Inhibitor [551393]
Membrane-associated lectin type-C Target Info Inhibitor [551393]
BioCyc Pathway PhospholipasesPWY66-374:C20 prostanoid biosynthesisPWY-6241:Thyroid hormone biosynthesisPWY-4983:Citrulline-nitric oxide cycle
KEGG Pathway Drug metabolism - other enzymes
Metabolic pathwaysstm00511:Other glycan degradationhsa04514:Cell adhesion molecules (CAMs)
T cell receptor signaling pathway
Autoimmune thyroid disease
Rheumatoid arthritishsa04610:Complement and coagulation cascadeshsa04080:Neuroactive ligand-receptor interaction
GnRH signaling pathway
Ovarian steroidogenesis
Prolactin signaling pathway
Thyroid hormone synthesis
Autoimmune thyroid diseasehsa00564:Glycerophospholipid metabolism
Ether lipid metabolism
Arachidonic acid metabolism
Linoleic acid metabolism
alpha-Linolenic acid metabolism
Metabolic pathways
Ras signaling pathway
Vascular smooth muscle contraction
Pancreatic secretion
Fat digestion and absorptionhsa04744:Phototransductionhsa04014:Ras signaling pathway
Rap1 signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Oocyte meiosis
Endocytosis
PI3K-Akt signaling pathway
AMPK signaling pathway
Focal adhesion
Adherens junction
Signaling pathways regulating pluripotency of stem cells
Long-term depression
Progesterone-mediated oocyte maturation
Pathways in cancer
Transcriptional misregulation in cancer
Proteoglycans in cancer
Glioma
Prostate cancer
Melanomahsa00052:Galactose metabolism
Glycerolipid metabolism
Sphingolipid metabolism
Glycosphingolipid biosynthesis - globo series
Lysosomehsa00590:Arachidonic acid metabolism
Platelet activation
Serotonergic synapsehsa04060:Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
Hematopoietic cell lineage
Non-alcoholic fatty liver disease (NAFLD)hsa04144:Endocytosis
Bile secretion
Toxoplasmosis
Hepatitis Chsa04610:Complement and coagulation cascadeshsa04071:Sphingolipid signaling pathway
Lysosome
Tuberculosishsa04974:Protein digestion and absorptionhsa00052:Galactose metabolism
Carbohydrate digestion and absorptionhsa04514:Cell adhesion molecules (CAMs)
Hematopoietic cell lineagehsa00330:Arginine and proline metabolism
Calcium signaling pathway
Phagosome
Circadian entrainment
Salivary secretion
Alzheimer's disease
Amyotrophic lateral sclerosis (ALS)hsa04071:Sphingolipid signaling pathway
Fc epsilon RI signaling pathway
Asthmahsa04145:Phagosome
Tuberculosis
Measles
NetPath Pathway TGF_beta_Receptor Signaling Pathway
TCR Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling PathwayNetPath_25:FSH Signaling Pathway
IL2 Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
TGF_beta_Receptor Signaling PathwayNetPath_11:TCR Signaling Pathway
IL2 Signaling PathwayNetPath_4:EGFR1 Signaling Pathway
PANTHER Pathway Blood coagulationP04394:Thyrotropin-releasing hormone receptor signaling pathwayP00028:Heterotrimeric G-protein signaling pathway-rod outer segment phototransductionP00032:Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
Insulin/IGF pathway-protein kinase B signaling cascadeP00031:Inflammation mediated by chemokine and cytokine signaling pathwayP00042:Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
Nicotinic acetylcholine receptor signaling pathwayP06959:CCKR signaling map ST
Pathway Interaction Database E2F transcription factor networkp75ntrpathway:p75(NTR)-mediated signalingnfat_tfpathway:Calcineurin-regulated NFAT-dependent transcription in lymphocytesglypican_1pathway:Glypican 1 networkreg_gr_pathway:Glucocorticoid receptor regulatory networkfcer1pathway:Fc-epsilon receptor I signaling in mast cellsrhodopsin_pathway:Visual signal transduction: Rodser_nongenomic_pathway:Plasma membrane estrogen receptor signaling
SHP2 signaling
IGF1 pathway
Posttranslational regulation of adherens junction stability and dissassembly
Integrins in angiogenesis
Stabilization and expansion of the E-cadherin adherens junctionlkb1_pathway:LKB1 signaling events
Ceramide signaling pathway
Direct p53 effectors
Validated nuclear estrogen receptor alpha network
PathWhiz Pathway Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone
Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/ChoriogonadotropinPW000148:Sphingolipid Metabolism
Galactose MetabolismPW000044:Arachidonic Acid MetabolismPW000153:Lactose Degradation
Galactose MetabolismPW000010:Arginine and Proline MetabolismPW000453:Fc Epsilon Receptor I Signaling in Mast Cells
Reactome ROS production in response to bacteria
Amyloid formationR-HSA-193634:Axonal growth inhibition (RHOA activation)R-HSA-389513:CTLA4 inhibitory signalingR-HSA-140837:Intrinsic Pathway of Fibrin Clot Formation
Common Pathway of Fibrin Clot FormationR-HSA-193048:Androgen biosynthesis
Thyroxine biosynthesis
Hormone ligand-binding receptors
G alpha (s) signalling eventsR-HSA-1482788:Acyl chain remodelling of PC
Acyl chain remodelling of PE
Acyl chain remodelling of PIR-HSA-2453902:The canonical retinoid cycle in rods (twilight vision)
Inactivation, recovery and regulation of the phototransduction cascade
G alpha (i) signalling eventsR-HSA-2428928:IRS-related events triggered by IGF1R
SHC-related events triggered by IGF1RR-HSA-1660662:Glycosphingolipid metabolismR-HSA-110056:MAPK3 (ERK1) activation
MAPK1 (ERK2) activationR-HSA-171052:LDL-mediated lipid transport
Chylomicron-mediated lipid transport
Retinoid metabolism and transportR-HSA-140837:Intrinsic Pathway of Fibrin Clot Formation
Common Pathway of Fibrin Clot FormationR-HSA-1442490:Collagen degradation
Metabolism of Angiotensinogen to Angiotensins
MHC class II antigen presentationR-HSA-202733:Cell surface interactions at the vascular wallR-HSA-1222556:ROS production in response to bacteria
Nitric oxide stimulates guanylate cyclaseR-HSA-2454202:Fc epsilon receptor (FCERI) signaling
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated NF-kB activationR-HSA-5621575:CD209 (DC-SIGN) signaling
WikiPathways NRF2 pathway
Nuclear Receptors Meta-Pathway
Heroin metabolism
Irinotecan Pathway
Fluoropyrimidine Activity
Phase I biotransformations, non P450WP2700:Latent infection of Homo sapiens with Mycobacterium tuberculosisWP2431:Spinal Cord InjuryWP2877:Vitamin D Receptor Pathway
T-Cell Receptor and Co-stimulatory Signaling
Allograft Rejection
Costimulation by the CD28 familyWP558:Complement and Coagulation Cascades
Formation of Fibrin Clot (Clotting Cascade)WP2749:Metabolism of steroid hormones and vitamin D
Metabolism of amino acids and derivatives
Peptide hormone biosynthesis
FSH signaling pathway
TSH signaling pathway
Thyroxine (Thyroid Hormone) Production
GPCR ligand binding
GPCR downstream signalingWP2740:Glycerophospholipid biosynthesisWP455:GPCRs, Class A Rhodopsin-like
Visual phototransduction
Regulation of Microtubule Cytoskeleton
Integrated Breast Cancer Pathway
Integrin-mediated Cell AdhesionWP615:Senescence and Autophagy in Cancer
Insulin Signaling
Endochondral Ossification
Focal Adhesion
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Apoptosis
Signaling Pathways in Glioblastoma
MicroRNAs in cardiomyocyte hypertrophyWP2788:Sphingolipid metabolismWP98:Prostaglandin Synthesis and Regulation
Arachidonic acid metabolism
Phase 1 - Functionalization of compounds
Eicosanoid Synthesis
Selenium Micronutrient NetworkWP706:SIDS Susceptibility Pathways
Senescence and Autophagy in Cancer
IL-6 signaling pathway
Differentiation Pathway
Interleukin-6 signalingWP710:DNA Damage Response (only ATM dependent)
Statin Pathway
Wnt Signaling Pathway
Wnt Signaling Pathway and Pluripotency
Lipid digestion, mobilization, and transport
Oncostatin M Signaling Pathway
SREBF and miR33 in cholesterol and lipid homeostasis
SREBP signalling
Folate Metabolism
Vitamin B12 Metabolism
Selenium Micronutrient NetworkWP558:Complement and Coagulation CascadesWP1848:Metabolism of carbohydratesWP1794:Cell surface interactions at the vascular wallWP229:Irinotecan PathwayWP727:Monoamine Transport
Myometrial Relaxation and Contraction Pathways
Amyotrophic lateral sclerosis (ALS)
Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
Spinal Cord Injury
Alzheimers Disease
Effects of Nitric Oxide
Serotonin Transporter ActivityWP2865:IL1 and megakaryotyces in obesity
Fc epsilon receptor (FCERI) signaling
References
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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