Drug Information

Drug General Information
Drug ID
D07MCA
Former ID
DNCL003337
Drug Name
FK949E
Drug Type
Small molecular drug
Indication Alcohol use disorders [ICD9: 303; ICD10:F10.2] Phase 3 [525091]
Company
Astellas
Structure
Download
2D MOL

3D MOL
Formula
C25H29N3O6S
Canonical SMILES
C1CN(CCN1CCOCCO)C2=NC3=CC=CC=C3SC4=CC=CC=C42.C(=CC(=O)O<br />)C(=O)O
InChI
1S/C21H25N3O2S.C4H4O4/c25-14-16-26-15-13-23-9-11-24(12-10-23)21-17-5-1-3-7-19(17)27-20-8-4-2-6-18(20)22-21;5-3(6)1-2-4(7)8/h1-8,25H,9-16H2;1-2H,(H,5,6)(H,7,8)/b;2-1+
InChIKey
VRHJBWUIWQOFLF-WLHGVMLRSA-N
PubChem Compound ID
6918224
PubChem Substance ID
12014721, 14859896, 17194751, 26719780, 43529610, 46386812, 46386911, 49681551, 49830367, 57371842, 79986831, 92308534, 92716943, 103770894, 104178668, 114787639, 124658986, 124800422, 126622592, 160871365, 164829097, 172080371, 179295964, 223936950, 226426384, 226426385, 243121791, 252160074
Target and Pathway
Target(s) 5-HT 2 receptor Target Info Modulator [526036], [534577]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
References
Ref 525091ClinicalTrials.gov (NCT02362412) Study to Evaluate the Effects of Switching Different Strength Forms of FK949E in Bipolar Disorder Patients With Major Depressive Episodes. U.S. National Institutes ofHealth.
Ref 526036D(2) and 5HT(2A) receptor occupancy of different doses of quetiapine in schizophrenia: a PET study. Eur Neuropsychopharmacol. 2001 Apr;11(2):105-10.
Ref 534577Time course of central nervous dopamine-D2 and 5-HT2 receptor blockade and plasma drug concentrations after discontinuation of quetiapine (Seroquel) in patients with schizophrenia. Psychopharmacology(Berl). 1998 Jan;135(2):119-26.

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