Drug Information

Drug General Information
Drug ID
D07MGA
Former ID
DAP001306
Drug Name
Hesperetin
Synonyms
Hesperin; Hesperitin; TNP00238; YSO2; Cyanidanon 4'-methyl ether 1626; Flavanone, 3',5,7-trihydroxy-4'-methoxy-(VAN); Flavanone, 3',5,7-trihydroxy-4'-methoxy-(VAN) (8CI); (-)-hesperetin; (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydro-4H-chromen-4-one; (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydrochromen-4-one; (S)-2,3-Dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyrone; (S)-2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one; 3',5,7-Trihydroxy-4'-methoxyflavanone; 3',5,7-Trihydroxy-4-methoxyflavanone; 4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (S)-(9CI); 5,7,3'-Trihydroxy-4'-methoxyflavanone
Drug Type
Small molecular drug
Indication High cholesterol level [ICD9: 272; ICD10:E78.0] Approved [552004]
Therapeutic Class
Anticholesteremic Agents
Structure
Download
2D MOL

3D MOL
Formula
C16H14O6
Canonical SMILES
COC1=C(C=C(C=C1)C2CC(=O)C3=C(C=C(C=C3O2)O)O)O
InChI
1S/C16H14O6/c1-21-13-3-2-8(4-10(13)18)14-7-12(20)16-11(19)5-9(17)6-15(16)22-14/h2-6,14,17-19H,7H2,1H3/t14-/m0/s1
InChIKey
AIONOLUJZLIMTK-AWEZNQCLSA-N
CAS Number
CAS 520-33-2
PubChem Compound ID
72281
PubChem Substance ID
4847, 597194, 877412, 8149172, 8195111, 10321847, 11112384, 11112385, 11336214, 11361453, 11363075, 11365637, 11368199, 11372127, 11375448, 11376361, 11462425, 11466152, 11467272, 11485481, 11485843, 11489609, 11490919, 11493749, 11493995, 11537620, 16889621, 24895619, 26613332, 26680108, 26744164, 26754195, 26754196, 29204220, 43128472, 46507998, 47365297, 47365298, 47440361, 47515405, 47515406, 47885508, 47959861, 48035231, 48110539, 48259342, 48421825, 49698360, 50069543, 50091682
ChEBI ID
ChEBI:28230
Target and Pathway
Target(s) Diglyceride acyltransferase Target Info Inhibitor [535956]
BioCyc Pathway Triacylglycerol biosynthesis
KEGG Pathway Glycerolipid metabolism
Retinol metabolism
Metabolic pathways
Fat digestion and absorption
PathWhiz Pathway Retinol Metabolism
Reactome Acyl chain remodeling of DAG and TAG
Triglyceride Biosynthesis
WikiPathways Vitamin A and Carotenoid Metabolism
Statin Pathway
Triacylglyceride Synthesis
Glycerophospholipid biosynthesis
Fatty acid, triacylglycerol, and ketone body metabolism
References
Ref 552004Drug information of Hesperetin, 2008. eduDrugs.
Ref 535956In vitro inhibition of diacylglycerol acyltransferase by prenylflavonoids from Sophora flavescens. Planta Med. 2004 Mar;70(3):258-60.

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