Drug Information

Drug General Information
Drug ID
D07MOX
Former ID
DAP000016
Drug Name
Norepinephrine
Synonyms
Adrenor; Aktamin; Arterenol; Levarterenol; Levarterenolo; Levoarterenol; Levonor; Levonoradrenaline; Levonorepinephrine; Levophed; Noradrenalin; Noradrenalina; Noradrenaline; Noradrenalinum; Noreinefrina; Norepinefrina; Norepinephrinum; Norepirenamine; Levarterenolo [DCIT]; Nor adrenalin; Noradrenalina [Italian]; Norepinephrine Noradrenalin; Sympathin E; LT03330026; LT4; ALBB-006229; L-Noradrenaline; L-Norepinephrine; L-arterenol; Nor adrenalin (TN); Noradrenaline (JP15); Noreinefrina [INN-Spanish]; Norepinephrine (INN); Norepinephrine [INN:JAN]; Norepinephrinum [INN-Latin]; L-3,4-dihydroxyphenylethanolamine; Norepinephrine l-Tartrate (1:1); D-(-)-Noradrenaline; D53D5E3A-2360-4CA9-8031-6C2CD4062FD5; L-alpha-(aminomethyl)-3,4-dihydroxybenzyl alcohol; L-1-(3,4-Dihydroxyphenyl)-2-aminoethanol; L-2-Amino-1-(3,4-dihydroxyphenyl)ethanol; (-)-(R)-Norepinephrine; (-)-Arterenol; (-)-Arterenol free base; (-)-NORADRENALINE; (-)-Norepinephrine; (-)-alpha-(Aminomethyl)protocatechuyl alcohol; (R)-(-)-Norepinephrine; (R)-4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol; (R)-Noradrenaline; (R)-Norepinephrine; 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-(9CI); 4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol; 4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol
Drug Type
Small molecular drug
Indication Septic shock; Neurogenic shock [ICD9: 785, 785.52; ICD10:R57.8, R65.21] Approved [468140], [538181]
Therapeutic Class
Vasoconstrictor Agents
Company
Bedford Laboratories
Structure
Download
2D MOL

3D MOL
Formula
C8H11NO3
InChI
InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/t8-/m0/s1
InChIKey
SFLSHLFXELFNJZ-QMMMGPOBSA-N
CAS Number
CAS 51-41-2
PubChem Compound ID
439260
PubChem Substance ID
3828, 840952, 841792, 7847144, 7980168, 8144526, 8149447, 10298272, 11335405, 11360644, 11363903, 11366465, 11369027, 11371679, 11373774, 11377189, 11461616, 11484784, 11488880, 11490336, 11491893, 11494823, 15898897, 22426371, 24714977, 24891196, 26512253, 26611841, 26679364, 26683762, 26754493, 26754494, 29215339, 36883508, 46394455, 46506201, 47291023, 47662149, 47959614, 48034990, 48259106, 48416337, 49892614, 50109852, 50109853, 51036046, 53788371, 56311831, 56313397, 57288371
ChEBI ID
ChEBI:18357
SuperDrug ATC ID
C01CA03
SuperDrug CAS ID
cas=000051412
Target and Pathway
Target(s) Beta-1 adrenergic receptor Target Info Stimulator [534841]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Adrenergic signaling in cardiomyocytes
Gap junction
Salivary secretion
Dilated cardiomyopathy
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta1 adrenergic receptor signaling pathway
PathWhiz Pathway Muscle/Heart Contraction
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Endothelin Pathways
GPCR ligand binding
GPCR downstream signaling
References
Ref 468140(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 505).
Ref 538181FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 040455.
Ref 534841Impact of exogenous beta-adrenergic receptor stimulation on hepatosplanchnic oxygen kinetics and metabolic activity in septic shock. Crit Care Med. 1999 Feb;27(2):325-31.

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