Drug Information

Drug General Information
Drug ID
D07MXA
Former ID
DNC000376
Drug Name
C75
Drug Type
Small molecular drug
Indication Obesity [ICD9: 278; ICD10:E66] Investigative [535480]
Structure
Download
2D MOL

3D MOL
Formula
C14H22O4
Canonical SMILES
CCCCCCCCC1C(C(=C)C(=O)O1)C(=O)O
InChI
1S/C14H22O4/c1-3-4-5-6-7-8-9-11-12(13(15)16)10(2)14(17)18-11/h11-12H,2-9H2,1H3,(H,15,16)/t11-,12+/m1/s1
InChIKey
VCWLZDVWHQVAJU-NEPJUHHUSA-N
CAS Number
CAS 191282-48-1
PubChem Compound ID
9881506
PubChem Substance ID
14847821, 24695827, 26740885, 26758695, 45628459, 53837775, 57373648, 77879576, 92711145, 103610284, 104107766, 126631158, 134339819, 152100035, 163122639, 163393237, 163688148, 164765421, 165225950, 198953192, 204378101, 206245597, 229062152, 252457542
Target and Pathway
Target(s) Fatty acid synthase Target Info Inhibitor [535480]
Carnitine O-palmitoyltransferase I Target Info Activator [535480]
BioCyc Pathway Fatty acid biosynthesis initiation
Fatty acid elongation -- saturated
Palmitate biosynthesis
KEGG Pathway Fatty acid biosynthesis
Metabolic pathways
Fatty acid metabolism
AMPK signaling pathway
Insulin signaling pathwayhsa00071:Fatty acid degradation
PPAR signaling pathway
Adipocytokine signaling pathway
Glucagon signaling pathway
Pathway Interaction Database p73 transcription factor network
Validated transcriptional targets of deltaNp63 isoforms
PathWhiz Pathway Fatty Acid BiosynthesisPW000023:Fatty acid Metabolism
Reactome ChREBP activates metabolic gene expression
Activation of gene expression by SREBF (SREBP)
Fatty Acyl-CoA BiosynthesisR-HSA-1368082:RORA activates gene expression
PPARA activates gene expression
Import of palmitoyl-CoA into the mitochondrial matrix
WikiPathways Fatty Acid Biosynthesis
Nuclear Receptors Meta-Pathway
Liver X Receptor Pathway
Activation of Gene Expression by SREBP (SREBF)
SREBF and miR33 in cholesterol and lipid homeostasis
SREBP signalling
Metabolism of water-soluble vitamins and cofactors
Integration of energy metabolism
Fatty acid, triacylglycerol, and ketone body metabolism
AMPK SignalingWP706:SIDS Susceptibility Pathways
Mitochondrial LC-Fatty Acid Beta-Oxidation
PPAR Alpha Pathway
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Circadian Clock
Fatty Acid Beta Oxidation
AMPK Signaling
References
Ref 535480C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity. Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9498-502. Epub 2002 Jun 11.
Ref 535480C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity. Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9498-502. Epub 2002 Jun 11.

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