Drug Information

Drug General Information
Drug ID
D07OCV
Former ID
DIB000082
Drug Name
HT-0712
Synonyms
IPL-455903; Small-molecule PDE4 inhibitors (memory disorders), Inflazyme/Helicon
Drug Type
Small molecular drug
Indication Cognitive disorders [ICD9: 290-294, 294.0, 780.09, 780.9, 780.93; ICD10:F01-F07, F04, F05, R41.3] Phase 2 [547671]
Company
Dart neuroscience
Structure
Download
2D MOL

3D MOL
Formula
C25H31NO3
Canonical SMILES
[C@H]1(C[C@H](CNC1=O)c1cc(c(cc1)OC)OC1CCCC1)Cc1cc(ccc1)<br />C
CAS Number
CAS 617720-02-2
PubChem Compound ID
9865375
Target and Pathway
Target(s) Type IV phosphodiesterase Target Info Inhibitor [543406]
CAMP-specific 3',5'-cyclic phosphodiesterase 4A Target Info Inhibitor [543404]
CAMP-specific 3',5'-cyclic phosphodiesterase 4B Target Info Inhibitor [543405]
KEGG Pathway Purine metabolism
cAMP signaling pathway
Morphine addictionhsa00230:Purine metabolism
Morphine addiction
NetPath Pathway IL5 Signaling Pathway
IL2 Signaling Pathway
PathWhiz Pathway Purine Metabolism
Reactome DARPP-32 events
G alpha (s) signalling eventsR-HSA-180024:DARPP-32 events
G alpha (s) signalling events
WikiPathways G Protein Signaling Pathways
Myometrial Relaxation and Contraction Pathways
TSH signaling pathwayWP35:G Protein Signaling PathwaysWP35:G Protein Signaling Pathways
Nuclear Receptors Meta-Pathway
Opioid Signalling
References
Ref 547671Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018324)
Ref 543404(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1300).
Ref 543405(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1301).
Ref 543406(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1303).

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