Drug Information

Drug General Information
Drug ID
D07QTG
Former ID
DIB018004
Drug Name
JNJ-479655
Drug Type
Small molecular drug
Indication Alzheimer disease [ICD9: 331; ICD10:G30] Clinical trial [532081]
Structure
Download
2D MOL
Formula
C28H32N4O2S
InChI
InChI=1S/C28H32N4O2S/c33-26(25-12-7-15-29-27(25)35-24-10-5-2-6-11-24)30-22-28(13-20-34-21-14-28)32-18-16-31(17-19-32)23-8-3-1-4-9-23/h1-12,15H,13-14,16-22H2,(H,30,33)
InChIKey
XREFXUCWSYMIOG-UHFFFAOYSA-N
PubChem Compound ID
66553218
PubChem Substance ID
152159784, 164135554, 187051839, 249896055, 252158758
Target and Pathway
Target(s) P2X purinoceptor 7 Target Info Antagonist [532440]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Reactome The NLRP3 inflammasome
WikiPathways Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
References
Ref 532081The role of the innate immune system in psychiatric disorders. Mol Cell Neurosci. 2013 Mar;53:52-62.
Ref 532440Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ-47965567. Br J Pharmacol. 2013 Oct;170(3):624-40.

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