Drug General Information
Drug ID	D07REK
Former ID	DNC009074
Drug Name	4-ethoxynaphthalene-1,2-dione
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529817]
Structure		Download 2D MOL 3D MOL
Formula	C12H10O3
Canonical SMILES	CCOC1=CC(=O)C(=O)C2=CC=CC=C21
InChI	1S/C12H10O3/c1-2-15-11-7-10(13)12(14)9-6-4-3-5-8(9)11/h3-7H,2H2,1H3
InChIKey	XPXODXIULRDWNT-UHFFFAOYSA-N
PubChem Compound ID	343759
Target and Pathway
Target(s)	Dual specificity protein phosphatase 1	Target Info	Inhibitor	[529817]
	M-phase inducer phosphatase 2	Target Info	Inhibitor	[529817]
KEGG Pathway	MAPK signaling pathway
	Serotonergic synapsehsa04010:MAPK signaling pathway
	Cell cycle
	Progesterone-mediated oocyte maturation
	MicroRNAs in cancer
NetPath Pathway	FSH Signaling Pathway
	IL2 Signaling Pathway
	EGFR1 Signaling Pathway
	Wnt Signaling Pathway
	TCR Signaling PathwayNetPath_14:IL2 Signaling Pathway
	TGF_beta_Receptor Signaling Pathway
Pathway Interaction Database	Fc-epsilon receptor I signaling in mast cells
	Regulation of p38-alpha and p38-beta
	Direct p53 effectors
	ErbB1 downstream signaling
	ATF-2 transcription factor network
	AP-1 transcription factor networkplk1_pathway:PLK1 signaling events
	FOXM1 transcription factor network
	p38 signaling mediated by MAPKAP kinases
	Aurora A signaling
Reactome	RAF-independent MAPK1/3 activation
	Negative regulation of MAPK pathwayR-HSA-157881:Cyclin B2 mediated events
	Cyclin A/B1 associated events during G2/M transition
	Cyclin A:Cdk2-associated events at S phase entry
WikiPathways	MAPK Signaling PathwayWP615:Senescence and Autophagy in Cancer
	MAPK Signaling Pathway
	Retinoblastoma (RB) in Cancer
	Prostate Cancer
	Integrated Breast Cancer Pathway
	Integrated Cancer pathway
	Mitotic G2-G2/M phases
	Cell Cycle
References
Ref 529817	Bioorg Med Chem. 2009 Mar 15;17(6):2276-81. Epub 2008 Nov 8.Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases.
Ref 529817	Bioorg Med Chem. 2009 Mar 15;17(6):2276-81. Epub 2008 Nov 8.Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases.

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