Drug Information

Drug General Information
Drug ID
D07SAQ
Former ID
DIB002684
Drug Name
Tie-2 inhibitors
Synonyms
Tek inhibitors (cancer), AstraZeneca; Tie-2 inhibitors (cancer); Tie-2 inhibitors (cancer), AstraZeneca
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Investigative [552059]
Company
AstraZeneca plc
Structure
Download
2D MOL

3D MOL
Canonical SMILES
n1cnc2c(c1N)nc(s2)c1n(cnc1c1ccccc1)Cc1ccccc1N1CCOCC1
Target and Pathway
Target(s) Angiopoietin 1 receptor Target Info Inhibitor [543511]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
HIF-1 signaling pathway
PI3K-Akt signaling pathway
Rheumatoid arthritis
NetPath Pathway Wnt Signaling Pathway
PANTHER Pathway Angiogenesis
Pathway Interaction Database Angiopoietin receptor Tie2-mediated signaling
SHP2 signaling
Reactome Tie2 Signaling
RAF/MAP kinase cascade
WikiPathways Wnt Signaling Pathway Netpath
Cell surface interactions at the vascular wall
Angiogenesis
References
Ref 552059Novel thienopyrimidine and thiazolopyrimidine kinase inhibitors with activity against Tie-2 in vitro and in vivo. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6670-4
Ref 543511(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1842).

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.