Drug General Information
Drug ID
D07SNW
Former ID
DNC006516
Drug Name
1,6-bis(4'-dimethylaminophenyl)-hexa-1,3,5-triene
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528161]
Structure
Download
2D MOL

3D MOL

Formula
C22H26N2
Canonical SMILES
CN(C)C1=CC=C(C=C1)C=CC=CC=CC2=CC=C(C=C2)N(C)C
InChI
1S/C22H26N2/c1-23(2)21-15-11-19(12-16-21)9-7-5-6-8-10-20-13-17-22(18-14-20)24(3)4/h5-18H,1-4H3/b6-5+,9-7+,10-8+
InChIKey
JGQHLETVKDCCET-NRIIQWGUSA-N
PubChem Compound ID
Target and Pathway
Target(s) Amyloid beta A4 protein Target Info Inhibitor [528161]
KEGG Pathway Notch signaling pathway
Alzheimer's disease
Reactome Nuclear signaling by ERBB4
Degradation of the extracellular matrix
Regulated proteolysis of p75NTR
NRIF signals cell death from the nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
EPH-ephrin mediated repulsion of cells
WikiPathways Notch Signaling Pathway
Signaling by ERBB4
Signaling by NOTCH3
Signaling by NOTCH4
Signaling by NOTCH1
Signaling by NOTCH2
Notch Signaling Pathway
Alzheimers Disease
Signalling by NGF
References
Ref 528161J Med Chem. 2006 May 4;49(9):2841-4.Synthesis of biphenyltrienes as probes for beta-amyloid plaques.
Ref 528161J Med Chem. 2006 May 4;49(9):2841-4.Synthesis of biphenyltrienes as probes for beta-amyloid plaques.

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