Drug Information

Drug General Information
Drug ID
D07SOO
Former ID
DAP000682
Drug Name
Methoxyflurane
Synonyms
Analgizer; Anecotan; Ingalan; Inhalan; Methofane; Methoflurane; Methofluranum; Methoxane; Methoxiflurane; Methoxifluranum;Methoxyfluoran; Methoxyfluorane; Methoxyfluran; Methoxyfluranum; Metofane; Metossiflurano; Metoxfluran; Metoxifluran; Metoxiflurano; Penthrane; Pentran; Pentrane; Metossiflurano [DCIT]; Methoxyflurane [Anaesthetics, volatile]; Methoxyfluranum [INN-Latin]; Metofane (VAN); Metoxiflurano [INN-Spanish]; Penthrane (TN); Penthrane (VAN); Methoxyflurane (USP/INN); Methoxyflurane [USAN:INN:BAN]; Methyl 1,1-difluoro-2,2-dichloroethyl ether; Ether, 2,2-dichloro-1,1-difluoroethyl methyl; (2,2-dichloro-1,1-difluoroethyl) methyl ether; 2,2-Dichloro-1,1-difluoro-1-methoxyethane; 2,2-Dichloro-1,1-difluoroethyl methyl ether
Drug Type
Small molecular drug
Indication Anesthesia [ICD9: 338; ICD10:R20.0] Approved [542250], [550732]
Therapeutic Class
Anesthetics
Structure
Download
2D MOL

3D MOL
Formula
C3H4Cl2F2O
InChI
InChI=1S/C3H4Cl2F2O/c1-8-3(6,7)2(4)5/h2H,1H3
InChIKey
RFKMCNOHBTXSMU-UHFFFAOYSA-N
CAS Number
CAS 76-38-0
PubChem Compound ID
4116
PubChem Substance ID
9720, 409141, 3219845, 7666803, 7847610, 8152583, 10535151, 12055768, 14772496, 29223224, 46508879, 48423662, 49855814, 50113268, 50702824, 57309755, 57322151, 103427852, 104305473, 117484889, 117650907, 118838651, 125374192, 129121548, 131498568, 132511622, 134337971, 134971540, 135586124, 136987072, 137004982, 143456706, 143799541, 144206179, 160964363, 162765240, 163788948, 164812131, 176318772, 178103808, 179225909, 184554813, 187072658, 198981352, 202542063, 204417825, 223439742, 226492719, 241138142, 249944760
SuperDrug ATC ID
N02BG09
SuperDrug CAS ID
cas=000076380
Target and Pathway
Target(s) Gamma-aminobutyric acid receptor subunit alpha-1 Target Info Antagonist [536555]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transport
References
Ref 542250(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7234).
Ref 550732Drug information of Methoxyflurane, 2008. eduDrugs.
Ref 536555DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. Epub 2007 Nov 29.

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