Drug Information

Drug General Information
Drug ID
D07SOQ
Former ID
DNC005911
Drug Name
N-(2-naphthylsulfonyl)-glycyl-glycine-nitrile
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527885]
Structure
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2D MOL

3D MOL
Formula
C14H13N3O3S
Canonical SMILES
C1=CC=C2C=C(C=CC2=C1)S(=O)(=O)NCC(=O)NCC#N
InChI
1S/C14H13N3O3S/c15-7-8-16-14(18)10-17-21(19,20)13-6-5-11-3-1-2-4-12(11)9-13/h1-6,9,17H,8,10H2,(H,16,18)
InChIKey
LVYWXNHSBUSHNC-UHFFFAOYSA-N
PubChem Compound ID
11652399
Target and Pathway
Target(s) Cathepsin S Target Info Inhibitor [527885]
KEGG Pathway Lysosome
Phagosome
Antigen processing and presentation
Tuberculosis
NetPath Pathway Leptin Signaling Pathway
IL2 Signaling Pathway
Reactome Endosomal/Vacuolar pathway
Degradation of the extracellular matrix
Trafficking and processing of endosomal TLR
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentation
WikiPathways Class I MHC mediated antigen processing & presentation
Trafficking and processing of endosomal TLR
References
Ref 527885J Med Chem. 2005 Dec 1;48(24):7688-707.Interaction of papain-like cysteine proteases with dipeptide-derived nitriles.
Ref 527885J Med Chem. 2005 Dec 1;48(24):7688-707.Interaction of papain-like cysteine proteases with dipeptide-derived nitriles.

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