Drug General Information
Drug ID	D07SZJ
Former ID	DIB014734
Drug Name	A-75169
Synonyms	A-74324; A-74325
Indication	Glaucoma [ICD9: 365; ICD10:H40-H42]		Terminated	[545494]
Company	Abbott Laboratories
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c12c(cc(cc2)O)CCCC1CN(CCc1ccccc1)C
CAS Number	CAS 125067-40-5
Target and Pathway
Target(s)	Alpha-2C adrenergic receptor	Target Info	Modulator	[550028]
KEGG Pathway	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
PANTHER Pathway	Alpha adrenergic receptor signaling pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome	Adrenoceptors
	Adrenaline signalling through Alpha-2 adrenergic receptor
	Adrenaline,noradrenaline inhibits insulin secretion
	G alpha (i) signalling events
	G alpha (z) signalling events
	Surfactant metabolism
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Platelet Aggregation (Plug Formation)
	Integration of energy metabolism
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 545494	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003469)
Ref 550028	A-75169 HCI: Pharmacological profile and ocular pharmacology studies of a new alpha-2 antagonist. Drug Development Research Volume 28, Issue 1, pages 56-64, January 1993.

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