Drug Information

Drug General Information
Drug ID
D07UHS
Former ID
DCL000804
Drug Name
Fingolimod
Synonyms
Gilenya (TN); 2-Amino-2-(4-octylphenethyl)propane-1,3-diol
Drug Type
Small molecular drug
Indication Primary progressive multiple sclerosis [ICD9: 340; ICD10:G35] Approved [531351], [539536]
Company
Novartis
Structure
Download
2D MOL

3D MOL
Formula
C19H33NO2
InChI
InChI=1S/C19H33NO2/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-22/h9-12,21-22H,2-8,13-16,20H2,1H3
InChIKey
KKGQTZUTZRNORY-UHFFFAOYSA-N
CAS Number
CAS 162359-55-9
PubChem Compound ID
107970
PubChem Substance ID
7980354, 10627340, 11538030, 14800795, 44436888, 50070757, 52231945, 91613352, 103298437, 104045114, 104380165, 112629137, 124899206, 125335078, 126522750, 126659901, 126665797, 128394615, 134339282, 135204658, 135626722, 135650261, 137003753, 140236536, 152344348, 160820803, 162221744, 163091250, 163838506, 164834614, 174006739, 175268765, 175426965, 175427125, 184527777, 204414213, 210274752, 210280385, 223660888, 223770775, 226398832, 242078815, 249836440, 251873579, 251916753, 251917992, 252214240, 252433026, 252478872
SuperDrug ATC ID
L04AA27
Drug Resistance Mutation (DRM)
DRM DRM Info
Target and Pathway
Target(s) Sphingosine 1-phosphate receptor 1 Target Info Modulator [531351], [536837]
KEGG Pathway FoxO signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
IL2 Signaling Pathway
Pathway Interaction Database Fc-epsilon receptor I signaling in mast cells
S1P3 pathway
S1P1 pathway
Sphingosine 1-phosphate (S1P) pathway
PDGFR-beta signaling pathway
Reactome G alpha (i) signalling events
Lysosphingolipid and LPA receptors
WikiPathways Signal Transduction of S1P Receptor
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 531351Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.
Ref 539536(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2407).
Ref 531351Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.
Ref 536837Emerging oral drugs for multiple sclerosis. Expert Opin Emerg Drugs. 2008 Sep;13(3):465-77.

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