Drug Information

Drug General Information
Drug ID
D07XYV
Former ID
DAP000250
Drug Name
Bambuterol
Synonyms
Bambec; Bambuterolum; Oxeol; Bambuterolum [Latin]; Terbutaline bisdimethylcarbamate; Bambec (TN); Bambuterol (INN); Bambuterol [BAN:INN]; KWD-2183; Oxeol (TN); Terbutaline bis(dimethylcarbamate); [3-[2-(tert-butylamino)-1-hydroxyethyl]-5-(dimethylcarbamoyloxy)phenyl] N,N-dimethylcarbamate; (+-)-5-(2-(tert-Butylamino)-1-hydroxyethyl)-m-phenylene bis(dimethylcarbamate); 5-(2-(tert-butylamino)-1-hydroxyethyl)-3-phenylene bis(dimethylcarbamate); 5-[2-(tert-butylamino)-1-hydroxyethyl]benzene-1,3-diyl bis(dimethylcarbamate)
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Approved [536361], [541721]
Therapeutic Class
Bronchodilator Agents
Company
AstraZeneca
Structure
Download
2D MOL

3D MOL
Formula
C18H29N3O5
InChI
InChI=1S/C18H29N3O5/c1-18(2,3)19-11-15(22)12-8-13(25-16(23)20(4)5)10-14(9-12)26-17(24)21(6)7/h8-10,15,19,22H,11H2,1-7H3
InChIKey
ANZXOIAKUNOVQU-UHFFFAOYSA-N
CAS Number
CAS 81732-46-9
PubChem Compound ID
54766
PubChem Substance ID
7505957, 7978757, 8183786, 11466389, 11467509, 11486138, 12012883, 14901744, 34718729, 46505785, 47425714, 47425715, 48319911, 48319912, 49698456, 49899434, 50124263, 51091713, 56463628, 57313660, 74398741, 85212435, 85787511, 87256882, 92308874, 94569210, 96099797, 103589983, 104305799, 117554637, 117887580, 124799605, 124893615, 125311917, 126653337, 126684150, 127434447, 131327158, 131857391, 134337564, 135013932, 137229225, 137619484, 160964677, 162177493, 164788080, 166234428, 172820776, 176484212, 178103214
SuperDrug ATC ID
R03CC12
SuperDrug CAS ID
cas=081732652
Target and Pathway
Target(s) Beta-2 adrenergic receptor Target Info Agonist [536563]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Adrenergic signaling in cardiomyocytes
Salivary secretion
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta2 adrenergic receptor signaling pathway
Pathway Interaction Database Arf6 trafficking events
Arf6 signaling events
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Vitamin D Receptor Pathway
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 541721(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6601).
Ref 536563Enantiomeric separation of beta2-agonists on macrocyclic antibiotic chiral stationary phases in high performance liquid chromatography. Pharmazie. 2007 Nov;62(11):836-40.

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