Drug General Information
Drug ID
D07YGH
Former ID
DCL000374
Drug Name
GSK239512
Drug Type
Small molecular drug
Indication Mild to moderate alzheimer disease; Dementia [ICD9: 290-294, 331.0; ICD10:F01-F07, G30] Phase 2 [524191]
Company
GSK
Structure
Download
2D MOL

3D MOL

Formula
C23H27N3O2
Canonical SMILES
C1CC(C1)N2CCC3=C(CC2)C=C(C=C3)OC4=NC=C(C=C4)N5CCCC5=O
InChI
1S/C23H27N3O2/c27-23-5-2-12-26(23)20-7-9-22(24-16-20)28-21-8-6-17-10-13-25(19-3-1-4-19)14-11-18(17)15-21/h6-9,15-16,19H,1-5,10-14H2
InChIKey
YFRBKEVUUCQYOW-UHFFFAOYSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Histamine H3 receptor Target Info Antagonist [550963]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Histamine receptors
G alpha (i) signalling events
WikiPathways Monoamine Transport
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 524191ClinicalTrials.gov (NCT01772199) Study to Assess Whether GSK239512 Can Remyelinate Lesions in Subjects With Relapsing Remitting Multiple Sclerosis. U.S. National Institutes of Health.
Ref 550963Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).

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