Drug Information

Drug General Information
Drug ID
D07YSQ
Former ID
DNC009643
Drug Name
N-(4-sulfamoylphenylethyl)-4-sulfamoylbenzamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551223]
Structure
Download
2D MOL

3D MOL
Formula
C15H17N3O5S2
Canonical SMILES
C1=CC(=CC=C1CCNC(=O)C2=CC=C(C=C2)S(=O)(=O)N)S(=O)(=O)N
InChI
1S/C15H17N3O5S2/c16-24(20,21)13-5-1-11(2-6-13)9-10-18-15(19)12-3-7-14(8-4-12)25(17,22)23/h1-8H,9-10H2,(H,18,19)(H2,16,20,21)(H2,17,22,23)
InChIKey
DTWPVNTYGDBHCV-UHFFFAOYSA-N
PubChem Compound ID
10385283
Target and Pathway
Target(s) Carbonic anhydrase I Target Info Inhibitor [551223]
Carbonic anhydrase IX Target Info Inhibitor [551223]
Carbonic anhydrase II Target Info Inhibitor [551223]
KEGG Pathway Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolism
Proximal tubule bicarbonate reclamation
Collecting duct acid secretion
Gastric acid secretion
Pancreatic secretion
Bile secretion
NetPath Pathway IL4 Signaling Pathway
EGFR1 Signaling Pathway
Pathway Interaction Database C-MYB transcription factor networkhif1_tfpathway:HIF-1-alpha transcription factor network
PathWhiz Pathway Gastric Acid Production
Reactome Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Reversible hydration of carbon dioxideR-HSA-1234158:Regulation of gene expression by Hypoxia-inducible Factor
Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
Reversible hydration of carbon dioxide
WikiPathways Reversible Hydration of Carbon Dioxide
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2877:Vitamin D Receptor Pathway
Regulation of Hypoxia-inducible Factor (HIF) by OxygenWP2770:Reversible Hydration of Carbon Dioxide
Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
References
Ref 551223Pteridine-sulfonamide conjugates as dual inhibitors of carbonic anhydrases and dihydrofolate reductase with potential antitumor activity. Bioorg Med Chem. 2010 Jul 15;18(14):5081-9. doi: 10.1016/j.bmc.2010.05.072. Epub 2010 Jun 2.
Ref 551223Pteridine-sulfonamide conjugates as dual inhibitors of carbonic anhydrases and dihydrofolate reductase with potential antitumor activity. Bioorg Med Chem. 2010 Jul 15;18(14):5081-9. doi: 10.1016/j.bmc.2010.05.072. Epub 2010 Jun 2.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.