Drug General Information
Drug ID	D08ALQ
Former ID	DIB003703
Drug Name	RPR-101821
Indication	Arteriosclerosis [ICD9: 440; ICD10:I70]		Terminated	[546131]
Company	Rhone-Poulenc Rorer Inc
Structure		Download 2D MOL 3D MOL
Canonical SMILES	n1c(oc2c1cccc2)c1ccc(CO[C@H]2[C@H](N)CCCC2)cc1.Cl
CAS Number	CAS 167504-53-2
Target and Pathway
Target(s)	Squalene synthetase	Target Info	Modulator	[534162]
BioCyc Pathway	Cholesterol biosynthesis II (via 24,25-dihydrolanosterol)
	Cholesterol biosynthesis III (via desmosterol)
	Cholesterol biosynthesis I
	Superpathway of cholesterol biosynthesis
	Epoxysqualene biosynthesis
KEGG Pathway	Steroid biosynthesis
	Metabolic pathways
	Biosynthesis of antibiotics
PANTHER Pathway	Cholesterol biosynthesis
PathWhiz Pathway	Steroid Biosynthesis
Reactome	Cholesterol biosynthesis
	PPARA activates gene expression
	Activation of gene expression by SREBF (SREBP)
WikiPathways	Statin Pathway
	Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
	Activation of Gene Expression by SREBP (SREBF)
	SREBP signalling
	Cholesterol Biosynthesis
	Cholesterol biosynthesis
References
Ref 546131	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006470)
Ref 534162	RPR 101821, a new potent cholesterol-lowering agent: inhibition of squalene synthase and 7-dehydrocholesterol reductase. Naunyn Schmiedebergs Arch Pharmacol. 1996 Jan;353(2):233-40.

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