TTD | Drug: D08AWI

Drug General Information
Drug ID	D08AWI
Former ID	DCL000937
Drug Name	PRX-00023
Drug Type	Small molecular drug
Indication	Severe mood disorders [ICD9: 296; ICD10:F30-F39]		Discontinued in Phase 2	[536580]
Company	Epix
Structure		Download 2D MOL 3D MOL
Formula	C23H38N4O3S
Canonical SMILES	CC(=O)NC1=CC=CC(=C1)N2CCN(CC2)CCCCNS(=O)(=O)CC3CCCCC3
InChI	1S/C23H38N4O3S/c1-20(28)25-22-10-7-11-23(18-22)27-16-14-26(15-17-27)13-6-5-12-24-31(29,30)19-21-8-3-2-4-9-21/h7,10-11,18,21,24H,2-6,8-9,12-17,19H2,1H3,(H,25,28)
InChIKey	SPWZXWDPAWDKQE-UHFFFAOYSA-N
CAS Number	CAS 740873-06-7
PubChem Compound ID	11430856
PubChem Substance ID	16528265, 23575255, 42509928, 76563664, 85210263, 96026038, 103488450, 104071376, 126680063, 134339380, 135262182, 139454000, 162222850, 198977761, 223680297, 226972933, 247147725
Target and Pathway
Target(s)	5-hydroxytryptamine 1A receptor	Target Info	Modulator
KEGG Pathway	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Serotonergic synapse
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PANTHER Pathway	5HT1 type receptor mediated signaling pathway
Reactome	Serotonin receptors
Reactome	G alpha (i) signalling events
WikiPathways	Serotonin HTR1 Group and FOS Pathway
	SIDS Susceptibility Pathways
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 536580	Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. Epub 2008 Jan 2.

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Drug Information